Tetrakis(triphenylphosphine)palladium (CAS 14221-01-3) Comprehensive Technical Guide
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | Specification | Alternative Catalysts |
|---|---|---|
| Chemical Formula | C72H60P4Pd | Pd(OAc)2, PdCl2 |
| Molecular Weight | 1155.56 g/mol | 224.51-326.43 g/mol |
| Appearance | Yellow-brown crystalline powder | Black crystals (PdO) |
| Melting Point | 103-107°C | N/A (varies by compound) |
| Pd Content | ≥9.2% | 45-60% (metal basis) |
| Solubility | Soluble in benzene, toluene; Insoluble in ether, water | Varies with ligands |
2. Key Applications in Catalytic Reactions
2.1 Cross-Coupling Reactions
- Suzuki-Miyaura Coupling: Enables aryl-aryl bond formation between boronic acids and halides
- Heck Reaction: Catalyzes coupling of alkenes with aryl/vinyl halides
- Sonogashira Coupling: Facilitates C(sp)-C(sp2) bond formation
2.2 Specialized Catalysis
- Carbonylation reactions under mild conditions
- Isomerization of allylic alcohols to ketones
- Oxidative coupling in heterocycle synthesis
3. Operational Guidelines & Best Practices
3.1 Storage Protocols
- Maintain at 2-8°C under argon atmosphere
- Protect from light using amber glass containers
- Maximize shelf life: 24 months when properly sealed
3.2 Reaction Setup
- Optimal catalytic loading: 0.5-5 mol%
- Recommended solvent systems: THF, DMF, toluene
- Oxygen-free conditions required (Schlenk techniques)
4. Industrial Application Scenarios
4.1 Pharmaceutical Intermediate Synthesis
Key role in manufacturing:
- Anticancer drug candidates (EGFR inhibitors)
- Antiviral compound scaffolds
- Chiral building blocks for CNS drugs
4.2 Advanced Material Production
- Conductive polymer synthesis
- OLED material development
- Nanoparticle functionalization
5. Verified Customer Implementations
Case Study 1: Specialty Chemical Manufacturer
- Application: High-throughput synthesis of biaryl compounds
- Result: 92% yield improvement vs. traditional catalysts
- Scale: 150 kg/month continuous production
Case Study 2: University Research Lab
- Application: Development of novel C-H activation methodology
- Result: Published in J. Am. Chem. Soc. (2023)
- Catalyst Loading: 0.8 mol% achieved 85% efficiency
6. Technical Consultation & Quotation
For bulk pricing, custom synthesis, or technical support:
| Contact Method | Details |
|---|---|
| Technical Support | Email: info@vivalr.com |
| Order Inquiries | Tel: (86) 15866781826 |
| Emergency Contact | 24/7 MSDS support available |



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