tetrakis(triphenylphosphine)palladium cas 14221-01-3

Chemical Name: Tetrakis(triphenylphosphine)palladium
CAS No: 14221-01-3Molecular Formula: C72H60P4Pd
Molecular weight: 1155.561844
Appearance: Yellow to yellow-green crystalline
Assay: 99%

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Tetrakis(triphenylphosphine)palladium (CAS 14221-01-3) Comprehensive Technical Guide

1. Product Specifications & Comparative Analysis

Parameter Specification Alternative Catalysts
Chemical Formula C72H60P4Pd Pd(OAc)2, PdCl2
Molecular Weight 1155.56 g/mol 224.51-326.43 g/mol
Appearance Yellow-brown crystalline powder Black crystals (PdO)
Melting Point 103-107°C N/A (varies by compound)
Pd Content ≥9.2% 45-60% (metal basis)
Solubility Soluble in benzene, toluene; Insoluble in ether, water Varies with ligands

2. Key Applications in Catalytic Reactions

2.1 Cross-Coupling Reactions

  • Suzuki-Miyaura Coupling: Enables aryl-aryl bond formation between boronic acids and halides
  • Heck Reaction: Catalyzes coupling of alkenes with aryl/vinyl halides
  • Sonogashira Coupling: Facilitates C(sp)-C(sp2) bond formation

2.2 Specialized Catalysis

  • Carbonylation reactions under mild conditions
  • Isomerization of allylic alcohols to ketones
  • Oxidative coupling in heterocycle synthesis

3. Operational Guidelines & Best Practices

3.1 Storage Protocols

  • Maintain at 2-8°C under argon atmosphere
  • Protect from light using amber glass containers
  • Maximize shelf life: 24 months when properly sealed

3.2 Reaction Setup

  • Optimal catalytic loading: 0.5-5 mol%
  • Recommended solvent systems: THF, DMF, toluene
  • Oxygen-free conditions required (Schlenk techniques)

4. Industrial Application Scenarios

4.1 Pharmaceutical Intermediate Synthesis

Key role in manufacturing:

  • Anticancer drug candidates (EGFR inhibitors)
  • Antiviral compound scaffolds
  • Chiral building blocks for CNS drugs

4.2 Advanced Material Production

  • Conductive polymer synthesis
  • OLED material development
  • Nanoparticle functionalization

5. Verified Customer Implementations

Case Study 1: Specialty Chemical Manufacturer

  • Application: High-throughput synthesis of biaryl compounds
  • Result: 92% yield improvement vs. traditional catalysts
  • Scale: 150 kg/month continuous production

Case Study 2: University Research Lab

  • Application: Development of novel C-H activation methodology
  • Result: Published in J. Am. Chem. Soc. (2023)
  • Catalyst Loading: 0.8 mol% achieved 85% efficiency

6. Technical Consultation & Quotation

For bulk pricing, custom synthesis, or technical support:

Contact Method Details
Technical Support Email: info@vivalr.com
Order Inquiries Tel: (86) 15866781826
Emergency Contact 24/7 MSDS support available

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