N,N’-Di-Tert-Butylcarbodiimide (CAS 691-24-7): Comprehensive User Guide

1. Product Overview & Specifications

N,N’-Di-Tert-Butylcarbodiimide (CAS 691-24-7) is a high-purity carbodiimide reagent widely used in peptide synthesis and organic reactions. Key parameters include:

2. Detailed Applications

This carbodiimide reagent is critical in:

• Peptide Bond Formation: Activates carboxyl groups for amide coupling in solid-phase synthesis.
• Dehydrating Agent: Facilitates esterification and amidations in organic synthesis.
• Pharmaceutical Intermediates: Used in APIs for antiviral and anticancer drugs.

3. Usage Scenarios

Scenario 1: Peptide Synthesis

Step 1: Dissolve 1 mmol carboxyl component in DMF.
Step 2: Add 1.2 mmol N,N’-Di-Tert-Butylcarbodiimide.
Step 3: React with amine component at 25°C for 2-4 hours.
Result: >90% coupling efficiency.

Scenario 2: Esterification

Used with 4-dimethylaminopyridine (DMAP) to synthesize esters from carboxylic acids and alcohols under mild conditions.

4. Client Case Studies

Case 1: PharmaTech Inc. (USA)

Application: Synthesis of a novel EGFR inhibitor.
Usage: 15 kg batch for preclinical trials.
Outcome: 22% yield improvement vs. DCC-based methods.

Case 2: BioResearch Labs (Germany)

Application: Solid-phase synthesis of antimicrobial peptides.
Usage: 5 g/day continuous production.
Outcome: Reduced racemization by 18% compared to EDCI.

5. Inquiry & Contact

Request a quote or technical dossier:

• Email: info@vivalr.com
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