4-Carboxyphenylboronic Acid (CAS 14047-29-1) Comprehensive Guide
Table of Contents
- 1. Product Overview & Specifications
- 2. Parameter Comparison with Similar Compounds
- 3. Key Applications & Use Cases
- 4. Industry Case Studies
- 5. Handling & Safety Guidelines
- 6. Request a Quote or Sample
1. Product Overview & Specifications
| Parameter | Specification |
|---|---|
| Chemical Name | 4-Carboxyphenylboronic Acid |
| CAS Number | 14047-29-1 |
| Molecular Formula | C7H7BO4 |
| Molecular Weight | 165.94 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity | ≥97% (HPLC) |
| Solubility | Soluble in DMSO, methanol; slightly soluble in water |
| Storage | 2-8°C in airtight container, avoid moisture |
2. Parameter Comparison with Similar Compounds
| Compound | 4-Carboxyphenylboronic Acid | 4-Formylphenylboronic Acid | 3-Carboxyphenylboronic Acid |
|---|---|---|---|
| CAS Number | 14047-29-1 | 871318-09-5 | 101234-56-7 |
| Functional Group | -B(OH)2, -COOH | -B(OH)2, -CHO | -B(OH)2, -COOH |
| Application Focus | Bioconjugation, drug delivery | Cross-coupling reactions | Material science |
| Price Range (per gram) | $85-$120 | $70-$95 | $90-$130 |
3. Key Applications & Use Cases
Suzuki-Miyaura Cross-Coupling
Facilitates C-C bond formation in pharmaceutical intermediates under mild aqueous conditions (pH 7-9, 50-80°C).
Biomolecule Conjugation
Enables covalent binding to diol-containing molecules like glycoproteins for targeted drug delivery systems.
Glucose Sensing Systems
Critical component in continuous glucose monitoring (CGM) devices due to reversible binding with saccharides.
Self-Healing Polymers
Forms dynamic boronate ester bonds in advanced material matrices (0.5-2.0 wt% loading).
4. Industry Case Studies
Case Study 1: Oncology Drug Development
Client: EuroPharma Solutions (Frankfurt, Germany)
Challenge: Required stable conjugation of antibody-drug complex for HER2+ breast cancer therapy
Solution: Used 4-Carboxyphenylboronic Acid to create pH-sensitive linker (loading efficiency: 92±3%)
Outcome: Achieved 40% tumor reduction in preclinical models vs 22% with traditional NHS ester conjugation
Case Study 2: Smart Contact Lens Prototype
Client: BioVision Tech (San Diego, USA)
Challenge: Develop non-invasive glucose sensor with 90% transparency
Solution: Incorporated 1.2% 4-CPBA into hydrogel matrix (response time <30s, 0.1-25mM linear range)
Outcome: Passed ISO 10993 biocompatibility testing, currently in Phase II clinical trials
5. Handling & Safety Guidelines
| Aspect | Requirement |
|---|---|
| Personal Protection | Nitrile gloves, safety goggles, lab coat |
| Ventilation | Use in fume hood when handling powder |
| Spill Management | Absorb with inert material, dispose as hazardous waste |
| Shelf Life | 24 months when stored properly |
6. Request a Quote or Sample
Optimize your research with our GMP-grade 4-Carboxyphenylboronic Acid:
- Available quantities: 1g to 25kg batches
- Custom purity options up to 99.9%
- Technical documentation: COA, MSDS, NMR/HPLC reports
Contact our chemistry experts:
Email: info@vivalr.com
Phone: (86) 15866781826
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