4-Nitro-N-methylphthalimide (CAS 41663-84-7) Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
Basic Chemical Properties
CAS Number: 41663-84-7
Molecular Formula: C9H6N2O4
Molecular Weight: 206.16 g/mol
Appearance: Light yellow crystalline powder
Melting Point: 158-162°C
Solubility: Soluble in DMF, DMSO; sparingly soluble in ethanol
Comparative Analysis
| Parameter | 4-Nitro-N-methylphthalimide | N-Methylphthalimide | 4-Chloro-N-methylphthalimide |
|---|---|---|---|
| Reactivity | High (nitro group) | Moderate | Moderate-High |
| Thermal Stability | Up to 250°C | Up to 220°C | Up to 230°C |
| Pharmaceutical Use | API Intermediate | Limited | Specialty Applications |
2. Key Applications & Industrial Uses
Pharmaceutical Intermediates
Widely used in synthesizing:
– Antifungal agents
– Kinase inhibitors
– Neuroprotective compounds
Agrochemical Production
Critical component for:
– Herbicide metabolites
– Insect growth regulators
– Soil treatment additives
Advanced Material Science
Essential for:
– High-performance polymer crosslinkers
– OLED precursor materials
– Specialty coating additives
3. Usage Scenarios & Best Practices
Scenario 1: Antifungal Drug Synthesis
Process Flow:
1. Nitro reduction under H2/Pd-C catalysis
2. Amide formation with triphosgene
3. Purification via recrystallization
Scenario 2: Polymer Modification
Recommended Protocol:
– Use 0.5-2.0% w/w in epoxy systems
– Cure at 120-150°C for optimal crosslinking
– Compatible with BPA-based resins
4. Client Success Stories
Case 1: PharmaTech Innovations
Challenge: Required high-purity intermediate for Phase III clinical trial material
Solution: Custom micronization (D90 < 50μm) with 99.8% HPLC purity
Outcome: Accelerated regulatory approval by 18%
Case 2: AgroShield Solutions
Challenge: Degradation issues in soil-applied herbicides
Solution: Co-formulation with 4-Nitro-N-methylphthalimide stabilizer
Result: Extended field efficacy by 40%
5. Technical Inquiry & Ordering
For technical specifications sheets or bulk pricing:
Email: info@vivalr.com
Tel: (86) 15866781826
Why Choose Us?
- ISO 9001-certified production
- Batch-to-batch consistency (RSD < 0.5%)
- Custom particle size distribution options



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