Comprehensive Guide to 2-Bromo-4-methylpyrimidine
Table of Contents
- Product Overview & Specifications
- Key Applications
- Usage Guidelines
- Industry Case Studies
- Contact for Custom Solutions
Product Overview & Specifications
| Parameter | 2-Bromo-4-methylpyrimidine | Comparable Compounds |
|---|---|---|
| CAS Number | 1000014-72-8 | 2-Chloro-4-methylpyrimidine (874285-19-7) |
| Molecular Formula | C5H5BrN2 | C5H5ClN2 |
| Molecular Weight | 173.01 g/mol | 128.56 g/mol |
| Appearance | White to off-white crystalline powder | Colorless liquid |
| Purity | ≥98% (HPLC) | ≥95% |
| Key Advantage | Superior leaving group for cross-coupling reactions | Lower reactivity in Suzuki-Miyaura couplings |
Key Applications
Pharmaceutical Intermediates
Widely used in synthesizing kinase inhibitors (e.g., EGFR inhibitors) and antiviral agents due to its optimal bromine substitution pattern.
Agrochemical Development
Critical component in creating novel fungicides targeting cytochrome P450 enzymes in plant pathogens.
Material Science
Building block for metal-organic frameworks (MOFs) with applications in gas storage and heterogeneous catalysis.
Usage Guidelines
Reaction Optimization
| Reaction Type | Recommended Conditions | Typical Yield |
|---|---|---|
| Suzuki Coupling | Pd(PPh3)4 (2 mol%), K2CO3, DME/H2O (3:1), 80°C | 78-85% |
| Buchwald-Hartwig | XPhos Pd G3 (1.5 mol%), Cs2CO3, dioxane, 100°C | 65-72% |
Industry Case Studies
Case 1: Anticancer Drug Development
Client: Top 10 Global Pharma Company
Challenge: Required high-purity intermediate for third-generation BTK inhibitor
Solution: Supplied 20kg GMP-grade material with ≤0.1% impurity profile
Outcome: Accelerated IND submission by 3 months
Case 2: OLED Materials Production
Client: Leading Display Manufacturer
Challenge: Needed custom brominated pyrimidine derivative for electron transport layer
Solution: Delivered 98.7% pure compound with batch-to-batch consistency <3% RSD
Outcome: Achieved 15% improvement in device lifetime
Contact for Technical Consultation
Email: info@vivalr.com
Phone: (86) 15866781826
Why Choose Us?
- Batch sizes from 100g to 500kg
- Custom synthesis and derivatization services
- Regulatory support for FDA/EMA submissions
Frequently Asked Questions
| Question | Answer |
|---|---|
| Lead Time for 1kg Quantity? | 2-3 weeks standard production |
| Storage Recommendations? | 2-8°C under inert atmosphere |
| Analytical Documentation? | Includes HPLC, NMR, MS spectra |


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