2-Bromo-4-methylpyrimidine

Product Name:2-Bromo-4-methylpyrimidine
CAS:130645-48-6
MFC5H5BrN2
MW:173.01
EINECS:200-589-5
MOL File:130645-48-6.mol

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Comprehensive Guide to 2-Bromo-4-methylpyrimidine

Table of Contents

Product Overview & Specifications

Parameter 2-Bromo-4-methylpyrimidine Comparable Compounds
CAS Number 1000014-72-8 2-Chloro-4-methylpyrimidine (874285-19-7)
Molecular Formula C5H5BrN2 C5H5ClN2
Molecular Weight 173.01 g/mol 128.56 g/mol
Appearance White to off-white crystalline powder Colorless liquid
Purity ≥98% (HPLC) ≥95%
Key Advantage Superior leaving group for cross-coupling reactions Lower reactivity in Suzuki-Miyaura couplings

Key Applications

Pharmaceutical Intermediates

Widely used in synthesizing kinase inhibitors (e.g., EGFR inhibitors) and antiviral agents due to its optimal bromine substitution pattern.

Agrochemical Development

Critical component in creating novel fungicides targeting cytochrome P450 enzymes in plant pathogens.

Material Science

Building block for metal-organic frameworks (MOFs) with applications in gas storage and heterogeneous catalysis.

Usage Guidelines

Reaction Optimization

Reaction Type Recommended Conditions Typical Yield
Suzuki Coupling Pd(PPh3)4 (2 mol%), K2CO3, DME/H2O (3:1), 80°C 78-85%
Buchwald-Hartwig XPhos Pd G3 (1.5 mol%), Cs2CO3, dioxane, 100°C 65-72%

Industry Case Studies

Case 1: Anticancer Drug Development

Client: Top 10 Global Pharma Company
Challenge: Required high-purity intermediate for third-generation BTK inhibitor
Solution: Supplied 20kg GMP-grade material with ≤0.1% impurity profile
Outcome: Accelerated IND submission by 3 months

Case 2: OLED Materials Production

Client: Leading Display Manufacturer
Challenge: Needed custom brominated pyrimidine derivative for electron transport layer
Solution: Delivered 98.7% pure compound with batch-to-batch consistency <3% RSD
Outcome: Achieved 15% improvement in device lifetime

Contact for Technical Consultation

Email: info@vivalr.com
Phone: (86) 15866781826

Why Choose Us?

  • Batch sizes from 100g to 500kg
  • Custom synthesis and derivatization services
  • Regulatory support for FDA/EMA submissions

Frequently Asked Questions

Question Answer
Lead Time for 1kg Quantity? 2-3 weeks standard production
Storage Recommendations? 2-8°C under inert atmosphere
Analytical Documentation? Includes HPLC, NMR, MS spectra
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