2-Methylthio-4-pyrimidinol

Product Name:2-Methylthio-4-pyrimidinol
CAS:5751-20-2
MFC5H6N2OS
MW:142.18
EINECS:227-274-6
MOL File:5751-20-2.mol

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Comprehensive Guide to 2-Methylthio-4-pyrimidinol (CAS 13605-25-1)

Table of Contents

1. Product Specifications & Key Parameters

Parameter Specification
Chemical Name 2-Methylthio-4-pyrimidinol
CAS Number 13605-25-1
Molecular Formula C5H6N2OS
Molecular Weight 142.18 g/mol
Appearance White to off-white crystalline powder
Purity (HPLC) ≥98% (Standard Grade), ≥99.5% (Pharma Grade)
Storage Conditions 2-8°C in airtight container, protected from light

2. Industrial Applications & Functional Uses

2.1 Pharmaceutical Intermediate

Critical component in synthesis of:

  • Antimalarial drugs (e.g., Pyrimethamine derivatives)
  • Antiviral agents targeting RNA replication
  • Kinase inhibitors for cancer therapy

2.2 Agrochemical Applications

  • Key precursor for systemic fungicides
  • Building block for plant growth regulators
  • Active ingredient in pesticide formulations

3. Comparative Analysis with Structural Analogs

Compound Reactivity Cost Efficiency Thermal Stability
2-Methylthio-4-pyrimidinol High nucleophilic activity $$$ (Mid-range) Stable up to 180°C
4-Pyrimidinol Moderate reactivity $$ (Lower cost) Decomposes at 150°C

4. Reaction Mechanisms & Catalytic Behavior

Demonstrates dual functionality in organocatalysis:

  • Thioether group enables radical transfer reactions
  • Hydroxyl group participates in hydrogen-bonding catalysis

5. Application Case Studies

Case 1: Antimalarial Drug Synthesis

Process parameters for Pyrimethamine precursor:

  • Yield improvement from 68% to 82% using optimized conditions
  • Reduced reaction time from 24h to 8h

6. Verified Customer Implementations

Customer A: European Pharma Manufacturer

  • Application: Large-scale antiviral production
  • Result: Achieved 99.3% API purity
  • Feedback: “Reliable quality with consistent batch-to-batch performance”

Customer B: Asian Agrochemical Company

  • Application: Novel fungicide development
  • Result: 40% cost reduction vs previous formulation

7. Request Customized Solutions

Contact our technical team for:

  • Bulk pricing (100kg+ orders)
  • Custom synthesis services
  • Regulatory support documentation

Email: info@vivalr.com
Tel: (86) 15866781826

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