Comprehensive Guide to 2-Methylthio-4-pyrimidinol (CAS 13605-25-1)
Table of Contents
- Product Overview & Specifications
- Key Applications & Industrial Uses
- Technical Comparison with Alternatives
- Mechanisms of Action in Chemical Reactions
- Case Studies in Pharmaceutical Synthesis
- Customer Success Stories
- Request Customized Quotation
1. Product Specifications & Key Parameters
| Parameter | Specification |
|---|---|
| Chemical Name | 2-Methylthio-4-pyrimidinol |
| CAS Number | 13605-25-1 |
| Molecular Formula | C5H6N2OS |
| Molecular Weight | 142.18 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity (HPLC) | ≥98% (Standard Grade), ≥99.5% (Pharma Grade) |
| Storage Conditions | 2-8°C in airtight container, protected from light |
2. Industrial Applications & Functional Uses
2.1 Pharmaceutical Intermediate
Critical component in synthesis of:
- Antimalarial drugs (e.g., Pyrimethamine derivatives)
- Antiviral agents targeting RNA replication
- Kinase inhibitors for cancer therapy
2.2 Agrochemical Applications
- Key precursor for systemic fungicides
- Building block for plant growth regulators
- Active ingredient in pesticide formulations
3. Comparative Analysis with Structural Analogs
| Compound | Reactivity | Cost Efficiency | Thermal Stability |
|---|---|---|---|
| 2-Methylthio-4-pyrimidinol | High nucleophilic activity | $$$ (Mid-range) | Stable up to 180°C |
| 4-Pyrimidinol | Moderate reactivity | $$ (Lower cost) | Decomposes at 150°C |
4. Reaction Mechanisms & Catalytic Behavior
Demonstrates dual functionality in organocatalysis:
- Thioether group enables radical transfer reactions
- Hydroxyl group participates in hydrogen-bonding catalysis
5. Application Case Studies
Case 1: Antimalarial Drug Synthesis
Process parameters for Pyrimethamine precursor:
- Yield improvement from 68% to 82% using optimized conditions
- Reduced reaction time from 24h to 8h
6. Verified Customer Implementations
Customer A: European Pharma Manufacturer
- Application: Large-scale antiviral production
- Result: Achieved 99.3% API purity
- Feedback: “Reliable quality with consistent batch-to-batch performance”
Customer B: Asian Agrochemical Company
- Application: Novel fungicide development
- Result: 40% cost reduction vs previous formulation
7. Request Customized Solutions
Contact our technical team for:
- Bulk pricing (100kg+ orders)
- Custom synthesis services
- Regulatory support documentation
Email: info@vivalr.com
Tel: (86) 15866781826


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