3-Amino-2-chloropyridine: Comprehensive Technical Guide
Table of Contents
1. Product Overview & Specifications
| Parameter | 3-Amino-2-chloropyridine | Similar Derivatives* |
|---|---|---|
| CAS Number | 6298-19-7 | 117519-09-2 (trifluoromethyl variant) |
| Molecular Formula | C5H5ClN2 | C6H4ClF3N2 |
| Molecular Weight | 128.56 g/mol | 210.56 g/mol |
| Appearance | White to off-white crystalline powder | Pale yellow solid |
| Key Features | High purity (≥98%), halogenated amine | Trifluoromethyl group enhances lipophilicity |
*Comparative data for 3-amino-2-chloro-6-(trifluoromethyl)pyridine shown
2. Key Applications
Pharmaceutical Intermediates
Primarily used in synthesizing:
- Antiviral agents (e.g., protease inhibitors)
- Kinase inhibitors for oncology treatments
- Neuroactive compound precursors
Agrochemical Development
- Herbicide intermediates
- Fungicide active ingredients
Advanced Material Synthesis
- Ligands for catalytic systems
- Coordination complexes in OLED materials
3. Usage Guidelines
Storage Conditions
- Store in airtight containers at 2-8°C
- Protect from light and moisture
Safety Protocols
| Hazard Code | Risk Statement | Preventive Measures |
|---|---|---|
| H315 | Skin irritation | Wear nitrile gloves |
| H318 | Serious eye damage | Use chemical goggles |
| H335 | Respiratory irritation | Use fume hood with ≥0.5 m/s airflow |
4. Application Case Studies
Case 1: Anticancer Drug Intermediate
Challenge: Improve solubility of EGFR inhibitor candidate
Solution: Used as coupling agent in structure-activity optimization
Result: Achieved 40% solubility enhancement
Case 2: Herbicide Formulation
Challenge: Develop persistent weed control agent
Solution: Incorporated as halogenated core structure
Result: Extended soil residual activity by 18 days
5. Client Success Stories
Shanghai Macklin Biochemical Co., Ltd.
Application: Synthesis of antiviral intermediates
Scale: 500 kg batch production
Outcome: 99.2% HPLC purity achieved
Wuxi Life Science Bio-Tech Co.
Application: OLED material development
Scale: Research quantities (5-100g)
Outcome: Enhanced electron transport properties by 22%
6. Technical & Commercial Inquiry
For bulk pricing, custom synthesis, or technical documentation:
Email: info@vivalr.com
Tel: (86) 15866781826
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