Contents
Pyrimidine-4-Carboxaldehyde Technical Profile
Chemical Specifications
| CAS Number | 2435-50-9 |
|---|---|
| Molecular Formula | C5H4N2O |
| Molecular Weight | 108.098 g/mol |
| Appearance | White to off-white crystalline powder |
Structural Comparison
| Parameter | Pyrimidine-4-Carboxaldehyde | Pyrimidine-5-Carboxaldehyde |
|---|---|---|
| Substitution Position | Position 4 | Position 5 |
| Reactivity | Higher electrophilicity | Moderate reactivity |
Performance Characteristics
| Density | 1.2±0.1 g/cm³ |
|---|---|
| Boiling Point | 225.3±13.0°C |
| Flash Point | 92.6±26.3°C |
| Storage | 2-8°C under inert atmosphere |
Pharmaceutical Applications
Therapeutic Development
- Key intermediate for kinase inhibitors
- Building block for antiviral compounds
- Precursor in anticancer drug synthesis
Material Science
- Ligand precursor for catalytic systems
- Cross-linking agent in polymer chemistry
Synthetic Pathways
Optimized Production Methods
- 4-Methylpyrimidine oxidation (72% yield)
- 4-(Dimethoxymethyl)pyrimidine conversion (26% yield)
Industry Implementations
Case Study 1: Oncology Research
A leading Swiss pharmaceutical company utilized this compound in developing third-generation EGFR inhibitors, achieving 40% improvement in selectivity profiles compared to previous analogs.
Case Study 2: Antiviral Development
Japanese researchers incorporated pyrimidine-4-carboxaldehyde derivatives in novel HCV protease inhibitors, demonstrating 98% viral load reduction in preclinical trials.
Technical Consultation
For bulk pricing, SDS documentation, or custom synthesis requirements:
Email: info@vivalr.com
Tel: (86) 15866781826
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