1. Product Overview & Specifications

2-Amino-3-bromo-5-fluoropyridine (CAS 374633-64-4) is a halogenated pyridine derivative widely used in pharmaceutical, agrochemical, and material science research. Below are its key parameters:

2. Key Applications

2.1 Pharmaceutical Intermediates

Widely used in synthesizing kinase inhibitors and antiviral agents due to its dual halogen substituents, enabling selective cross-coupling reactions.

2.2 Agrochemical Development

Essential for creating next-generation herbicides with improved leaf permeability and environmental persistence.

2.3 Material Science

Serves as a building block for photoactive compounds in OLED technologies.

3. Usage Scenarios

3.1 Suzuki-Miyaura Coupling

Example: Reacting with arylboronic acids under Pd catalysis to create bipyridine scaffolds for drug candidates.

3.2 Nucleophilic Substitution

Replacement of bromine with amines to develop antibacterial quinolone derivatives.

4. Client Case Studies

4.1 Vertex Pharmaceuticals

Challenge: Required a stable intermediate for cystic fibrosis drug candidates.
Solution: Used 2-Amino-3-bromo-5-fluoropyridine in palladium-mediated cross-couplings.
Result: Achieved 92% yield in lead optimization phase.

4.2 Syngenta AG

Challenge: Needed selective halogenation for herbicide resistance.
Solution: Incorporated compound into heterocyclic core structures.
Result: Developed 40% more potent formulations vs. previous generation.

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