3-HYDROXY-6-METHYL-2-NITROPYRIDINE: Technical Guide & Applications
Table of Contents
1. Product Overview & Specifications
3-Hydroxy-6-methyl-2-nitropyridine (CAS 100037-84-3) is a high-purity intermediate widely used in pharmaceuticals, agrochemicals, and organic synthesis. Key parameters:
| Parameter | Specification |
|---|---|
| Molecular Formula | C₆H₆N₂O₃ |
| Purity | ≥98% (HPLC) |
| Appearance | Yellow crystalline powder |
| Melting Point | 152-154°C |
Comparative Analysis
| Feature | 3-Hydroxy-6-methyl-2-nitropyridine | Similar Nitropyridine Derivatives |
|---|---|---|
| Solubility | Soluble in DMSO, Ethanol | Limited solubility in polar solvents |
| Stability | Stable at room temperature | Requires refrigeration |
2. Key Applications & Use Cases
Pharmaceutical Intermediates
Used in synthesizing antiviral and antitumor agents due to its nitro-group reactivity.
Agrochemicals
Key component in herbicides and fungicides for crop protection.
Material Science
Facilitates crosslinking in polymer coatings and electronic materials.
3. Industry Case Studies
Case Study 1: Pharmaceutical Manufacturer (Germany)
- Challenge: Low yield in kinase inhibitor synthesis.
- Solution: Optimized reaction using 3-Hydroxy-6-methyl-2-nitropyridine as a directing group.
- Result: 22% yield improvement; API approved in Phase III trials.
Case Study 2: Agrochemical Company (India)
- Challenge: Degradation of fungicide under UV light.
- Solution: Formulated UV-stable derivative using this compound.
- Result: Extended field efficacy by 40%.
4. Technical Comparison
Advantages over alternative intermediates:
- Higher regioselectivity in electrophilic substitutions
- Lower toxicity profile (LD50 > 500 mg/kg)
- Compatible with continuous flow chemistry systems
5. Contact for Quotation
Request custom synthesis batches (1kg to ton-scale):
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