2,4-Dichloro-5-trifluoromethylpyrimidine

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2,4-Dichloro-5-trifluoromethylpyrimidine: Comprehensive User Guide

Table of Contents

1. Product Overview & Specifications

Parameter Specification
Chemical Name 2,4-Dichloro-5-(trifluoromethyl)pyrimidine
CAS Number 1037836-71-8
Molecular Formula C5H2Cl2F3N2
Purity ≥98% (HPLC)
Storage Conditions 2-8°C in inert atmosphere

2. Key Applications & Use Cases

Pharmaceutical Intermediates

Critical building block for kinase inhibitors (e.g., EGFR inhibitors) and antiviral agents. Enables precise functional group modifications in drug discovery pipelines.

Agrochemical Synthesis

Used in fungicide development targeting cytochrome bc1 complex inhibitors, with enhanced environmental stability compared to traditional pyrimidine derivatives.

3. Performance Comparison

Compound Reactivity Thermal Stability Synthetic Yield
2,4-Dichloro-5-trifluoromethylpyrimidine High (SNAr reactions) Stable up to 150°C 85-92%
2-Chloro-4-fluoropyrimidine Moderate Decomposes at 80°C 70-75%

4. Usage Guidelines

Suzuki Coupling Protocol

  1. Charge reactor with 1.2 eq boronic acid under N2
  2. Maintain 80°C for 6-8 hours
  3. Monitor conversion via LC-MS

5. Client Case Studies

Case 1: Agrochemical Manufacturer (Switzerland)

Developed next-gen fungicide with 40% improved field persistence using our compound as key intermediate. Achieved 97% purity in final API.

Case 2: Oncology Research Center (USA)

Enabled synthesis of 15 novel EGFR inhibitor candidates through selective amine substitutions. Reduced lead optimization cycle time by 3 months.

6. Request Customized Solutions

Contact our technical team for batch-specific COA, MSDS, and bulk pricing:

Email: info@vivalr.com
Tel: (86) 15866781826

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