2,4-Dichloro-5-trifluoromethylpyrimidine: Comprehensive User Guide
Table of Contents
- 1. Product Overview & Specifications
- 2. Key Applications & Use Cases
- 3. Performance Comparison with Similar Compounds
- 4. Step-by-Step Usage Guidelines
- 5. Real-World Client Case Studies
- 6. Request Customized Quotation
1. Product Overview & Specifications
| Parameter | Specification |
|---|---|
| Chemical Name | 2,4-Dichloro-5-(trifluoromethyl)pyrimidine |
| CAS Number | 1037836-71-8 |
| Molecular Formula | C5H2Cl2F3N2 |
| Purity | ≥98% (HPLC) |
| Storage Conditions | 2-8°C in inert atmosphere |
2. Key Applications & Use Cases
Pharmaceutical Intermediates
Critical building block for kinase inhibitors (e.g., EGFR inhibitors) and antiviral agents. Enables precise functional group modifications in drug discovery pipelines.
Agrochemical Synthesis
Used in fungicide development targeting cytochrome bc1 complex inhibitors, with enhanced environmental stability compared to traditional pyrimidine derivatives.
3. Performance Comparison
| Compound | Reactivity | Thermal Stability | Synthetic Yield |
|---|---|---|---|
| 2,4-Dichloro-5-trifluoromethylpyrimidine | High (SNAr reactions) | Stable up to 150°C | 85-92% |
| 2-Chloro-4-fluoropyrimidine | Moderate | Decomposes at 80°C | 70-75% |
4. Usage Guidelines
Suzuki Coupling Protocol
- Charge reactor with 1.2 eq boronic acid under N2
- Maintain 80°C for 6-8 hours
- Monitor conversion via LC-MS
5. Client Case Studies
Case 1: Agrochemical Manufacturer (Switzerland)
Developed next-gen fungicide with 40% improved field persistence using our compound as key intermediate. Achieved 97% purity in final API.
Case 2: Oncology Research Center (USA)
Enabled synthesis of 15 novel EGFR inhibitor candidates through selective amine substitutions. Reduced lead optimization cycle time by 3 months.
6. Request Customized Solutions
Contact our technical team for batch-specific COA, MSDS, and bulk pricing:
Email: info@vivalr.com
Tel: (86) 15866781826


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