2,4,5-Trichloropyrimidine: Technical Guide for Industrial Applications
Table of Contents
1. Product Overview & Specifications
2,4,5-Trichloropyrimidine (CAS: 5750-76-5) is a halogenated pyrimidine derivative widely used as a versatile intermediate in organic synthesis. Its molecular formula is C4HCl3N2, with a molecular weight of 183.423 g/mol.
| Parameter | Value | Comparison with Analogues |
|---|---|---|
| Density | 1.6 g/cm³ | Higher reactivity than dichloro variants |
| Boiling Point | 258.5°C (760 mmHg) 96°C (12 mmHg) |
Lower volatility under vacuum |
| Flash Point | 135.1°C | Requires standard flammability precautions |
| LogP | 2.44 | Optimized for lipid membrane penetration |
2. Key Applications
This compound serves critical roles in:
- Pharmaceutical Synthesis: Intermediate for kinase inhibitors (e.g., ceritinib API)
- Agrochemicals: Building block for herbicidal compounds
- Material Science: Precursor for flame-retardant additives
3. Usage Guidelines
Handling Protocols:
- Store under inert gas (N2) at 2-8°C
- Use corrosion-resistant reactors for chlorination steps
- Typical reaction scale: 0.1-5 mol in batch processes
4. Industry Case Studies
Case 1: Anticancer Drug Intermediate
A major European pharma company achieved 92% yield in ceritinib precursor synthesis through optimized coupling reactions using 2,4,5-trichloropyrimidine.
5. Client Success Stories
| Client | Application | Outcome |
|---|---|---|
| Suizhou Hongqi Chemical | API Intermediate Production | Scaled to 500kg/month batches |
| Hubei Zhonglong Kangsheng | Crop Protection Agents | 20% Cost reduction vs. traditional routes |
6. Contact for Custom Solutions
Our technical team specializes in developing tailored synthesis protocols for 2,4,5-trichloropyrimidine derivatives. Reach out for formulation support or bulk inquiries:
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