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Specialized in2,4,5-Trichloropyrimidineand related product development and production

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2,4,5-Trichloropyrimidine: Technical Guide for Industrial Applications

Table of Contents

1. Product Overview & Specifications

2,4,5-Trichloropyrimidine (CAS: 5750-76-5) is a halogenated pyrimidine derivative widely used as a versatile intermediate in organic synthesis. Its molecular formula is C4HCl3N2, with a molecular weight of 183.423 g/mol.

Parameter Value Comparison with Analogues
Density 1.6 g/cm³ Higher reactivity than dichloro variants
Boiling Point 258.5°C (760 mmHg)
96°C (12 mmHg)		 Lower volatility under vacuum
Flash Point 135.1°C Requires standard flammability precautions
LogP 2.44 Optimized for lipid membrane penetration

2. Key Applications

This compound serves critical roles in:

  • Pharmaceutical Synthesis: Intermediate for kinase inhibitors (e.g., ceritinib API)
  • Agrochemicals: Building block for herbicidal compounds
  • Material Science: Precursor for flame-retardant additives

3. Usage Guidelines

Handling Protocols:

  • Store under inert gas (N2) at 2-8°C
  • Use corrosion-resistant reactors for chlorination steps
  • Typical reaction scale: 0.1-5 mol in batch processes

4. Industry Case Studies

Case 1: Anticancer Drug Intermediate
A major European pharma company achieved 92% yield in ceritinib precursor synthesis through optimized coupling reactions using 2,4,5-trichloropyrimidine.

5. Client Success Stories

Client Application Outcome
Suizhou Hongqi Chemical API Intermediate Production Scaled to 500kg/month batches
Hubei Zhonglong Kangsheng Crop Protection Agents 20% Cost reduction vs. traditional routes

6. Contact for Custom Solutions

Our technical team specializes in developing tailored synthesis protocols for 2,4,5-trichloropyrimidine derivatives. Reach out for formulation support or bulk inquiries:

info@vivalr.com
(86) 15866781826

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Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
5000+ square meters R&D center
A 70+ R&D team led by Chinese and foreign doctors
150 pieces (sets) of R&D equipment, 120+ fume hoods
18 patents

Solid QMS. Offer top-quality products and services.

Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
It has successfully passed on-site inspections from the United States, Australia, Poland, Japan and domestic pharmaceutical company customers and institutions many times, providing high-quality one-stop services for R&D and production of new drugs around the world.

More than 150 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

About the company

International Standard Chemicals Sell To All Over The World

FAQ

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Support, please make an appointment one day in advance. Company address: Room 716, Building 3, Ligao International Garden, No.1222 West Aoti Road, Lixia District, Jinan City, Shandong Province, P.R. China

Whether to provide samples?

Free samples can be provided for low value products, and small packaging specifications can be purchased for high value products.

Delivery time

Under normal circumstances, all items are in stock and will be shipped before 4 o'clock on the same day. Some products are produced to order, depending on the workshop situation and production schedule.

What is the production capacity?

At present, the company's workshop production equipment is mainly based on laboratories and pilot lines, with a maximum daily production capacity of 1.5 tons.

Can additional test indicators be added?

We can provide moisture, UV, IR, HNMR, CNMR, two-dimensional nuclear magnetic spectroscopy, optical rotation detection, elemental analysis, TGA analysis and residue analysis and other related tests to support personalized needs.

Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Chem-iso’s delivery rate is guaranteed to be 99.99%

5000+

square meter R&D center

150+

China(set) of R&D equipment

150+

Fume hood

180+

R&D team

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