Parameter | Specification |
---|---|
Chemical Name | 3-Bromo-2-Hydroxy-5-Methylpyridine |
CAS Number | 1072-97-5 |
Molecular Formula | C6H6BrNO |
Molecular Weight | 188.02 g/mol |
Appearance | White to off-white crystalline powder |
Purity (HPLC) | ≥99.0% |
Storage Conditions | 2-8°C in airtight container |
Widely used in synthesis of kinase inhibitors and antiviral agents. The bromine substituent enables efficient cross-coupling reactions for drug candidate diversification.
Essential precursor for novel fungicides and herbicides, particularly effective in creating compounds with enhanced bioactivity and environmental stability.
Building block for metal-organic frameworks (MOFs) and coordination polymers with potential applications in catalysis and gas storage.
Feature | 3-Bromo-2-Hydroxy-5-Methylpyridine | Similar Compound A | Similar Compound B |
---|---|---|---|
Reactivity in Suzuki Coupling | High (k = 0.45 min-1) | Moderate (k = 0.28 min-1) | Low (k = 0.12 min-1) |
Thermal Stability | Stable up to 250°C | Decomposes at 180°C | Stable up to 200°C |
Aqueous Solubility | 1.2 mg/mL (25°C) | 0.8 mg/mL | 2.1 mg/mL |
Step 1: Palladium-catalyzed cross-coupling with boronic acids
Step 2: Selective hydroxyl protection
Step 3: Final API purification
Used in three-step synthesis of next-generation fungicides showing 92% efficacy against Phytophthora infestans in field trials.
Challenge: Required high-purity intermediate for Phase III oncology drug
Solution: Custom synthesis with >99.5% purity
Result: 30% faster regulatory approval process
Challenge: Develop cost-effective fungicide with reduced environmental impact
Solution: Optimized 4-step synthesis route using our compound
Result: Achieved 40% production cost reduction vs traditional methods
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