Carbonic Acid, Methyl 2,2,2-Trifluoroethyl Ester (CAS 156783-95-8): Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
Carbonic Acid, Methyl 2,2,2-Trifluoroethyl Ester (CAS 156783-95-8) is a fluorinated ester compound widely used in organic synthesis, pharmaceutical intermediates, and specialty chemical manufacturing. Below are its key specifications:
| Parameter | Specification |
|---|---|
| Chemical Name | Carbonic Acid, Methyl 2,2,2-Trifluoroethyl Ester |
| CAS Number | 156783-95-8 |
| Molecular Formula | C4H5F3O3 |
| Molecular Weight | 170.08 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Purity | ≥98% (GC) |
| Boiling Point | 85-87°C at 760 mmHg |
| Density | 1.35 g/cm³ |
| Solubility | Miscible with organic solvents (e.g., DCM, THF) |
Comparative Advantages
| Feature | This Product | Similar Esters |
|---|---|---|
| Thermal Stability | High (>150°C) | Moderate (100-120°C) |
| Fluorine Content | 3 Fluorine atoms | 1-2 Fluorine atoms |
| Reactivity | High (due to trifluoroethyl group) | Standard |
2. Key Applications
- Pharmaceutical Intermediates: Used in synthesizing trifluoroethyl-containing APIs for antiviral and anticancer drugs.
- Agrochemicals: Key component in fluorinated pesticides and herbicides.
- Electronics: Serves as a solvent in lithium-ion battery electrolytes.
- Polymer Chemistry: Building block for fluorinated polymers with enhanced chemical resistance.
3. Usage Guidelines
Handling & Storage
- Store in a cool, dry place (2-8°C) under inert gas (N₂/Ar).
- Use corrosion-resistant equipment (e.g., glass or PTFE-lined containers).
Reaction Conditions
- Optimal temperature: 40-60°C in anhydrous environments.
- Compatible with catalysts like DBU or DMAP.
4. Industry Use Cases
Case 1: Antiviral Drug Synthesis
Process: Reacted with nucleoside analogs to introduce trifluoroethyl groups, improving metabolic stability. Yield: 82%.
Case 2: Fluorinated Herbicide Production
Process: Used as an alkylating agent in a Grignard reaction. Reduced reaction time by 30% compared to alternatives.
5. Client Success Stories
Client A: Top-tier Pharma Company (Europe)
- Challenge: Needed a stable intermediate for a Phase III oncology drug.
- Solution: Supplied 98.5% purity product under cGMP conditions.
- Result: Accelerated scale-up by 6 months; FDA approval secured in 2023.
Client B: Agrochemical Manufacturer (USA)
- Challenge: Required cost-effective fluorination for a new herbicide.
- Solution: Customized bulk delivery with 24/7 technical support.
- Result: 20% cost reduction and 15% higher field efficacy.
6. Contact for Inquiries
Request a quote, sample, or technical dossier:
- Email: info@vivalr.com
- Phone: (86) 15866781826



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