4′-Bromoacetanilide (CAS 103-88-8): Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
4′-Bromoacetanilide (CAS 103-88-8) is a brominated aromatic compound widely used as an intermediate in pharmaceuticals and organic synthesis. Below are its key specifications:
Parameter | Specification | Comparison: 4′-Chloroacetanilide |
---|---|---|
Molecular Formula | C8H8BrNO | C8H8ClNO |
Molecular Weight | 214.06 g/mol | 169.61 g/mol |
Appearance | White crystalline powder | Off-white powder |
Melting Point | 167-169°C | 135-137°C |
Purity | ≥99% (HPLC) | ≥98% |
Storage | 2-8°C in airtight container | Room temperature |
2. Key Applications
- Pharmaceutical Intermediates: Critical for synthesizing analgesics (e.g., phenacetin) and antipyretics.
- Organic Synthesis: Used in Suzuki-Miyaura cross-coupling reactions to create biaryl compounds.
- Dye Manufacturing: Serves as a precursor for brominated dye molecules.
- R&D: Employed in academic and industrial research for novel compound development.
3. Usage Guidelines
Example: Synthesis of Phenacetin
- Alkylation: React 4′-Bromoacetanilide with ethyl iodide in the presence of K2CO3.
- Hydrolysis: Treat the intermediate with HCl to remove the acetyl group.
- Ethoxylation: React with ethylene oxide under controlled pH to yield phenacetin.
Safety: Use PPE (gloves, goggles) and work in a fume hood due to bromine volatility.
4. Case Studies
Case 1: Antipyretic Drug Production
A European pharmaceutical company achieved 92% yield in paracetamol synthesis by optimizing bromoacetanilide reaction stoichiometry.
Case 2: OLED Material Development
A Japanese tech firm used 4′-Bromoacetanilide to synthesize a blue-light-emitting polymer, enhancing device efficiency by 15%.
5. Client Success Stories
Client A: Indian Pharma Manufacturer
Challenge: Low purity (85%) in analgesic intermediate synthesis.
Solution: Switched to our ≥99% purity 4′-Bromoacetanilide.
Result: Purity increased to 98.5%, reducing FDA approval time by 6 months.
Client B: German Chemical Company
Challenge: Side reactions during cross-coupling.
Solution: Custom micronized product for better solubility.
Result: Reaction efficiency improved from 72% to 89%.
6. Request a Quote
Contact us for premium 4′-Bromoacetanilide (CAS 103-88-8):
- Email: info@vivalr.com
- Phone: (86) 15866781826
Why Choose Us?
- ISO 9001-certified production
- Batch-specific COA
- Global shipping (DHL/FedEx)
- Technical support 24/7