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Specialized in4′-Bromoacetanilide Cas 103-88-8and related product development and production

Chemical Name: 4′-Bromoacetanilide
Synonyms: N-(4-Bromophenyl)acetamide; Acet-p-bromoanilide
CAS No.: 103-88-8
Molecular Fomula: C8H8BrNO
Molecular weight: 214.06
Appearance: white to beige or light gray Crystalline powder

Samples: Available / Stock: Sufficient
Estimated delivery time: 3-5 days

4′-Bromoacetanilide (CAS 103-88-8): Comprehensive User Guide

1. Product Overview & Specifications

4′-Bromoacetanilide (CAS 103-88-8) is a brominated aromatic compound widely used as an intermediate in pharmaceuticals and organic synthesis. Below are its key specifications:

Parameter Specification Comparison: 4′-Chloroacetanilide
Molecular Formula C8H8BrNO C8H8ClNO
Molecular Weight 214.06 g/mol 169.61 g/mol
Appearance White crystalline powder Off-white powder
Melting Point 167-169°C 135-137°C
Purity ≥99% (HPLC) ≥98%
Storage 2-8°C in airtight container Room temperature

2. Key Applications

  • Pharmaceutical Intermediates: Critical for synthesizing analgesics (e.g., phenacetin) and antipyretics.
  • Organic Synthesis: Used in Suzuki-Miyaura cross-coupling reactions to create biaryl compounds.
  • Dye Manufacturing: Serves as a precursor for brominated dye molecules.
  • R&D: Employed in academic and industrial research for novel compound development.

3. Usage Guidelines

Example: Synthesis of Phenacetin

  1. Alkylation: React 4′-Bromoacetanilide with ethyl iodide in the presence of K2CO3.
  2. Hydrolysis: Treat the intermediate with HCl to remove the acetyl group.
  3. Ethoxylation: React with ethylene oxide under controlled pH to yield phenacetin.

Safety: Use PPE (gloves, goggles) and work in a fume hood due to bromine volatility.

4. Case Studies

Case 1: Antipyretic Drug Production

A European pharmaceutical company achieved 92% yield in paracetamol synthesis by optimizing bromoacetanilide reaction stoichiometry.

Case 2: OLED Material Development

A Japanese tech firm used 4′-Bromoacetanilide to synthesize a blue-light-emitting polymer, enhancing device efficiency by 15%.

5. Client Success Stories

Client A: Indian Pharma Manufacturer

Challenge: Low purity (85%) in analgesic intermediate synthesis.
Solution: Switched to our ≥99% purity 4′-Bromoacetanilide.
Result: Purity increased to 98.5%, reducing FDA approval time by 6 months.

Client B: German Chemical Company

Challenge: Side reactions during cross-coupling.
Solution: Custom micronized product for better solubility.
Result: Reaction efficiency improved from 72% to 89%.

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Over 1000 cases. Synthesize complex compounds.

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Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Chem-iso’s delivery rate is guaranteed to be 99.99%

5000+

square meter R&D center

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China(set) of R&D equipment

150+

Fume hood

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R&D team

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