4′-Bromoacetanilide Cas 103-88-8

Chemical Name: 4′-Bromoacetanilide
Synonyms: N-(4-Bromophenyl)acetamide; Acet-p-bromoanilide
CAS No.: 103-88-8
Molecular Fomula: C8H8BrNO
Molecular weight: 214.06
Appearance: white to beige or light gray Crystalline powder

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4′-Bromoacetanilide (CAS 103-88-8): Comprehensive User Guide

1. Product Overview & Specifications
2. Key Applications
3. Usage Guidelines
4. Case Studies
5. Client Success Stories
6. Request a Quote

1. Product Overview & Specifications

4′-Bromoacetanilide (CAS 103-88-8) is a brominated aromatic compound widely used as an intermediate in pharmaceuticals and organic synthesis. Below are its key specifications:

Parameter	Specification	Comparison: 4′-Chloroacetanilide
Molecular Formula	C₈H₈BrNO	C₈H₈ClNO
Molecular Weight	214.06 g/mol	169.61 g/mol
Appearance	White crystalline powder	Off-white powder
Melting Point	167-169°C	135-137°C
Purity	≥99% (HPLC)	≥98%
Storage	2-8°C in airtight container	Room temperature

2. Key Applications

Pharmaceutical Intermediates: Critical for synthesizing analgesics (e.g., phenacetin) and antipyretics.
Organic Synthesis: Used in Suzuki-Miyaura cross-coupling reactions to create biaryl compounds.
Dye Manufacturing: Serves as a precursor for brominated dye molecules.
R&D: Employed in academic and industrial research for novel compound development.

3. Usage Guidelines

Example: Synthesis of Phenacetin

Alkylation: React 4′-Bromoacetanilide with ethyl iodide in the presence of K₂CO₃.
Hydrolysis: Treat the intermediate with HCl to remove the acetyl group.
Ethoxylation: React with ethylene oxide under controlled pH to yield phenacetin.

Safety: Use PPE (gloves, goggles) and work in a fume hood due to bromine volatility.

4. Case Studies

Case 1: Antipyretic Drug Production

A European pharmaceutical company achieved 92% yield in paracetamol synthesis by optimizing bromoacetanilide reaction stoichiometry.

Case 2: OLED Material Development

A Japanese tech firm used 4′-Bromoacetanilide to synthesize a blue-light-emitting polymer, enhancing device efficiency by 15%.

5. Client Success Stories

Client A: Indian Pharma Manufacturer

Challenge: Low purity (85%) in analgesic intermediate synthesis.
Solution: Switched to our ≥99% purity 4′-Bromoacetanilide.
Result: Purity increased to 98.5%, reducing FDA approval time by 6 months.

Client B: German Chemical Company

Challenge: Side reactions during cross-coupling.
Solution: Custom micronized product for better solubility.
Result: Reaction efficiency improved from 72% to 89%.

6. Request a Quote

Email: info@vivalr.com
Phone: (86) 15866781826

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4′-Bromoacetanilide Cas 103-88-8

4′-Bromoacetanilide (CAS 103-88-8): Comprehensive User Guide

Table of Contents

1. Product Overview & Specifications

2. Key Applications