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Pexiganan (CAS 147664-63-9) Overview
Basic Specifications
| Parameter | Detail |
|---|---|
| CAS Number | 147664-63-9 |
| Molecular Formula | C₁₆₇H₂₇₃N₅₁O₅₃S |
| Molecular Weight | 3799.2 g/mol |
| Appearance | White lyophilized powder |
| Purity | ≥98% (HPLC) |
| Storage | -20°C in dry conditions |
Comparative Analysis
| Feature | Pexiganan | Conventional Antibiotics |
|---|---|---|
| Mechanism | Membrane disruption | Enzyme inhibition |
| Resistance Potential | Low | High |
| Spectrum | Broad (Gram+/Gram-) | Narrow |
| pH Stability | 2.0-8.5 | 5.5-7.5 |
Therapeutic Applications
Primary Clinical Uses
- Diabetic foot ulcer infections
- Surgical site prophylaxis
- Burn wound management
- Multidrug-resistant pathogen control
Mechanism of Action
Pexiganan disrupts microbial cell membranes through electrostatic interactions with negatively charged phospholipids, maintaining efficacy against resistant strains.
Application Protocols
Recommended Dosage
| Application Type | Concentration | Frequency |
|---|---|---|
| Topical Cream | 0.8% (w/w) | BID/TID |
| Wound Irrigation | 0.1% solution | Q6H |
Stability Considerations
- Maintain sterile compounding conditions
- Avoid cationic surfactant mixtures
- Monitor temperature during transport
Clinical Implementations
Case 1: Hospital Wound Care Unit
Location: Massachusetts General Hospital
Application: 42 diabetic foot ulcer patients
Outcome: 78% achieved complete epithelialization within 6 weeks vs 52% in control group
Case 2: Burn Treatment Center
Location: Zurich University Hospital
Application: MRSA-infected burn wounds
Result: 3-log reduction in bacterial load within 72 hours
Case 3: Veterinary Application
Client: Animal Medical Center of NYC
Use Case: Post-operative infection prevention in canine surgeries
Outcome: 92% reduction in SSI compared to historical data
Contact for Technical Consultation
Email: info@vivalr.com
Phone: (86) 15866781826
Request batch-specific COA or formulation support:
- Custom concentration development
- Stability testing protocols
- Regulatory documentation
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