Chemical Name: (4R,6R)-tert-Butyl-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate
CAS No.:125995-13-3
Appearance: Light yellow to green or pale blue, viscous liquid
Assay：≥99.0%
A chiral building block with molecular formula C₁₆H₂₉NO₄, molecular weight 299.41 g/mol. White crystalline powder with 98.5% minimum purity by HPLC. Storage requirement: 2-8°C in inert atmosphere.
| Parameter | Specification | Competitor A | Competitor B |
|---|---|---|---|
| Purity | ≥98.5% | 97.0-98.0% | 95.5-97.5% |
| Optical Purity | 99.2% ee | 98.5% ee | 97.8% ee |
| Thermal Stability | Stable ≤40°C | Degrades at 35°C | Degrades at 30°C |
Critical intermediate in statin drug production, particularly for atorvastatin and rosuvastatin calcium. Enables precise stereochemical control in HMG-CoA reductase inhibitors.
Used in asymmetric catalysis development and chiral ligand synthesis for:
| Condition | Specification |
|---|---|
| Solubility | 25 mg/mL in DCM |
| Reaction Temperature | -20°C to 25°C |
| Incompatibilities | Strong oxidizers, acids |
Challenge: Required 99% enantiomeric excess for FDA submission batch
Solution: Implemented our material in critical asymmetric step
Outcome: Achieved 99.3% ee, reduced purification steps by 40%
Project: Development of novel chiral catalysts
Application: Used as precursor in ligand synthesis
Result: Published in J. Org. Chem. (2023), achieved 92% yield
For batch-specific COA, custom synthesis requirements, or bulk pricing:
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