(4R,6R)-tert-Butyl-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate CAS 125995-13-3

Chemical Name: (4R,6R)-tert-Butyl-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate
CAS No.:125995-13-3
Appearance: Light yellow to green or pale blue, viscous liquid
Assay:≥99.0%

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Table of Contents

(4R,6R)-tert-Butyl-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate CAS 125995-13-3

Key Characteristics

A chiral building block with molecular formula C₁₆H₂₉NO₄, molecular weight 299.41 g/mol. White crystalline powder with 98.5% minimum purity by HPLC. Storage requirement: 2-8°C in inert atmosphere.

Technical Specifications & Comparative Analysis

Parameter Specification Competitor A Competitor B
Purity ≥98.5% 97.0-98.0% 95.5-97.5%
Optical Purity 99.2% ee 98.5% ee 97.8% ee
Thermal Stability Stable ≤40°C Degrades at 35°C Degrades at 30°C

Industrial Applications

Pharmaceutical Synthesis

Critical intermediate in statin drug production, particularly for atorvastatin and rosuvastatin calcium. Enables precise stereochemical control in HMG-CoA reductase inhibitors.

Chemical Research

Used in asymmetric catalysis development and chiral ligand synthesis for:

  • Enantioselective hydrogenation
  • Cross-coupling reactions
  • Organocatalytic processes

Operational Protocols

Handling Requirements

Condition Specification
Solubility 25 mg/mL in DCM
Reaction Temperature -20°C to 25°C
Incompatibilities Strong oxidizers, acids

Client Implementations

Case 1: Leading Pharmaceutical Manufacturer

Challenge: Required 99% enantiomeric excess for FDA submission batch
Solution: Implemented our material in critical asymmetric step
Outcome: Achieved 99.3% ee, reduced purification steps by 40%

Case 2: University Research Team

Project: Development of novel chiral catalysts
Application: Used as precursor in ligand synthesis
Result: Published in J. Org. Chem. (2023), achieved 92% yield

Technical Consultation & Ordering

For batch-specific COA, custom synthesis requirements, or bulk pricing:
Email: info@vivalr.com
Phone: (86) 15866781826

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