4-(Trifluoromethyl)benzonitrile (CAS 455-18-5) Comprehensive Technical Guide
Table of Contents
- Product Specifications & Comparative Analysis
- Industrial Applications & Functional Mechanisms
- Operational Best Practices & Safety Protocols
- Client Implementation Case Studies
- Procurement Consultation & Technical Support
1. Product Specifications & Comparative Analysis
| Parameter | Specification | Grade Comparison |
|---|---|---|
| Chemical Formula | C8H4F3N | Pharma Grade vs Industrial Grade |
| Molecular Weight | 171.12 g/mol | ±0.5% Tolerance |
| Melting Point | 36°C – 41°C | USP vs EP Standards |
| Boiling Point | 80-81°C @ 20mmHg | Different Purification Methods |
| Density | 1.278 g/cm³ | Batch Consistency Analysis |
2. Industrial Applications & Functional Mechanisms
Pharmaceutical Intermediate: Critical precursor for fluorinated drug molecules including kinase inhibitors and antiviral compounds. Enables precise trifluoromethyl group introduction in nucleophilic aromatic substitution reactions.
Agrochemical Synthesis: Key building block for crop protection agents requiring enhanced lipophilicity and metabolic stability through fluorine substitution.
Material Science: Functional component in liquid crystal polymers and advanced fluorinated coatings with improved thermal/chemical resistance.
3. Operational Best Practices & Safety Protocols
Handling Requirements: Use nitrogen-purged environments for thermal processing above 50°C to prevent decomposition
Storage Conditions: Maintain in sealed containers under inert gas at 2-8°C with <60% relative humidity
Exposure Controls: Implement fume hoods with ≥100 fpm face velocity and NIOSH-approved respirators for particulate filtration
4. Client Implementation Case Studies
Case Study 1: Top 10 Pharma Company – Achieved 32% yield improvement in PDE4 inhibitor synthesis through optimized coupling reactions using 4-(Trifluoromethyl)benzonitrile
Case Study 2: Agrochemical Leader – Developed next-gen fungicide with 3x environmental persistence using our GMP-grade material
Technical Metrics:
| Application | Purity Requirement | Batch Success Rate |
|---|---|---|
| API Synthesis | ≥99.7% | 98.2% |
| Crop Science | ≥99.0% | 99.5% |
5. Procurement Consultation & Technical Support
Our chemical engineering team provides:
- Custom synthesis scale-up from lab to production (50g → 500kg batches)
- Regulatory documentation support (REACH, FDA DMF filings)
- Just-in-time delivery with ISO-certified cold chain logistics
Contact our technical specialists:
Email: info@vivalr.com
Tel: (86) 15866781826
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