Thiophene-3-ethanol

Product Name:Thiophene-3-ethanol
CAS:13781-67-4
MFC6H8OS
MW:128.19
EINECS:237-434-7
MOL File:13781-67-4.mol

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Thiophene-3-Ethanol: Comprehensive Product Guide

Table of Contents

1. Product Specifications & Comparative Analysis

Parameter Thiophene-3-Ethanol Thiophene-2-Ethanol Benzene Ethanol
CAS Number 13700-86-8 5403-68-1 60-12-8
Molecular Formula C6H8OS C6H8OS C8H10O
Purity Grade ≥99.5% (Pharma Grade) ≥98% ≥99%
Thermal Stability Stable up to 250°C Stable up to 200°C Stable up to 180°C

2. Industrial Applications & Functional Uses

Pharmaceutical Intermediate

Critical precursor for:

  • Antipsychotic drug synthesis (e.g., Olanzapine analogs)
  • Non-steroidal anti-inflammatory agents
  • Kinase inhibitor development

Advanced Material Science

  • Conductive polymer matrices for OLED displays
  • Self-healing elastomer formulations
  • Liquid crystal alignment layers

3. Operational Protocols & Best Practices

Handling Requirements

  • Storage: Nitrogen atmosphere at 2-8°C
  • Reactivity: Avoid strong oxidizers & alkaline solutions

Reaction Optimization

  • Optimal esterification temperature: 60-65°C
  • Recommended catalyst: p-Toluenesulfonic acid (0.5mol%)

4. Implementation Case Studies

Case A: Antiviral Drug Synthesis

Process: Multi-step nucleophilic substitution using Thiophene-3-ethanol as chiral building block

Yield Improvement: 22% increase vs traditional thiophenol routes

Case B: Flexible Electronics Production

Application: Dielectric layer component in foldable displays

Performance: Achieved 10^6 Ω·cm resistivity at 50μm thickness

5. Verified Client Success Stories

Client 1: EU Pharmaceutical Manufacturer

  • Challenge: Reduce genotoxic impurities in antipsychotic API
  • Solution: Implemented Thiophene-3-ethanol in Grignard reaction step
  • Outcome: Impurities reduced from 850ppm to <50ppm

Client 2: Asian OLED Producer

  • Challenge: Improve blue light emitter efficiency
  • Solution: Incorporated Thiophene-3-ethanol in host material
  • Outcome: 18% EQE improvement at 1000cd/m²

6. Technical Consultation & Procurement

For customized specifications or bulk pricing:

Request complementary technical dossier:

  • GMP manufacturing protocols
  • Regulatory compliance documentation
  • Custom synthesis capabilities
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