5-CHLORO-3-METHYLBENZO[B]THIOPHENE

Table of Contents

• Product Overview & Key Specifications
• Detailed Applications
• Usage Guidelines
• Industry Case Studies
• Request Quotation

5-Chloro-3-methylbenzo[b]thiophene: Product Overview & Key Specifications

Basic Parameters

Comparative Analysis

Detailed Applications

Pharmaceutical Intermediate

Critical building block for kinase inhibitors (JAK2, BTK) and antipsychotic drug candidates. Enables efficient functionalization at C-2 position for structure-activity relationship studies.

Organic Synthesis

Used in:

• Suzuki-Miyaura cross-coupling reactions
• Directed ortho-metalation reactions
• Heterocyclic ring expansion strategies

Material Science

Key component in:

• Organic semiconductors (HOMO level -5.4 eV)
• Liquid crystalline materials
• Photovoltaic cell research

Usage Guidelines

Best Practices

1. Handle under inert atmosphere (N2/Ar) for moisture-sensitive reactions
2. Use fresh DMF as solvent for Buchwald-Hartwig aminations
3. Purify via column chromatography (hexane:EtOAc 4:1)

Safety Protocols

• PPE Requirements: Nitrile gloves, safety goggles
• First Aid Measures: Flush eyes with water for 15 minutes if exposed
• Disposal: Follow local hazardous waste regulations

Industry Case Studies

Case 1: Anticancer Drug Development

Client: Top 10 Global Pharma Company
Challenge: Needed to synthesize 200g of JAK2 inhibitor intermediate within 6 weeks
Solution: Optimized Pd-catalyzed coupling using our compound (85% yield)
Result: Accelerated preclinical timeline by 3 months

Case 2: OLED Material Research

Client: Leading Display Manufacturer
Challenge: Required high-purity (>99.5%) material for emission layer
Solution: Provided recrystallized batch with 99.7% purity
Result: Achieved 15% improvement in device efficiency

Request Quotation

Contact our technical team for:

• Bulk pricing (1kg+ orders)
• Custom synthesis options
• Analytical data sheets

Email: info@vivalr.com
Phone: (86) 15866781826
Response Time: <24 hours for technical queries