3-Bromo-5-chlorobenzoic Acid: Technical Overview & Applications
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | 3-Bromo-5-chlorobenzoic Acid | Analogous Compounds |
|---|---|---|
| CAS Number | 42860-02-6 | 176548-70-2 (3-Bromo-5-fluorobenzoic acid) |
| Molecular Formula | C7H4O2ClBr | C7H4BrFO2 |
| Molecular Weight | 235.46 g/mol | 219.01 g/mol |
| Purity | ≥98% | Varies by supplier |
| Melting Point | 197°C | 238-248°C (3-Bromo-5-nitrobenzoic acid) |
| Solubility | Methanol-soluble | Dependent on substituents |
Key Advantage: Enhanced stability compared to halogen-substituted analogs, making it preferable for pharmaceutical synthesis.
2. Detailed Applications
Pharmaceutical Intermediates
Widely used in the synthesis of active pharmaceutical ingredients (APIs), particularly in:
- Antibacterial agents
- Non-steroidal anti-inflammatory drugs (NSAIDs)
- Kinase inhibitors
Agrochemical Development
- Key precursor for herbicides with selective action
- Used in fungicide formulations
Material Science
- Building block for liquid crystal materials
- Polymer modification agent
3. Operational Guidelines
Handling & Storage
- Store in airtight containers at 2-8°C
- Use in well-ventilated areas with PPE (gloves, goggles)
- Avoid contact with strong oxidizers
Reaction Optimization
- Optimal coupling reactions: 0-5°C in anhydrous DMF
- Catalyst recommendation: Pd(PPh3)4 for cross-coupling reactions
4. Case Studies
Case 1: Antibiotic Intermediate Synthesis
Client: European Pharma Company
Application: Synthesis of novel quinolone antibiotic
Result: 22% yield improvement compared to previous brominated analogs
Case 2: OLED Material Development
Client: Asian Electronics Manufacturer
Application: Electron transport layer material
Result: Achieved 15% higher luminescence efficiency
5. Client Success Stories
Shanghai Jixiang Bio-Technology
Application: NSAID precursor production
Outcome: Scaled production to 500kg/month with 99.5% purity
YuHan Chemical Co., Ltd.
Application: Custom synthesis for agrochemicals
Outcome: Developed patent-pending herbicide formula
6. Contact for Custom Solutions
For technical specifications, bulk pricing, or custom synthesis requirements:
Email: info@vivalr.com
Tel: (86) 15866781826
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