3-BROMO-5-CHLOROBENZOIC ACID

Product Name:3-BROMO-5-CHLOROBENZOIC ACID
CAS:42860-02-6
MFC7H4BrClO2
MW:235.46
EINECS:
MOL File:42860-02-6.mol

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3-Bromo-5-chlorobenzoic Acid: Technical Overview & Applications

1. Product Specifications & Comparative Analysis

Parameter 3-Bromo-5-chlorobenzoic Acid Analogous Compounds
CAS Number 42860-02-6 176548-70-2 (3-Bromo-5-fluorobenzoic acid)
Molecular Formula C7H4O2ClBr C7H4BrFO2
Molecular Weight 235.46 g/mol 219.01 g/mol
Purity ≥98% Varies by supplier
Melting Point 197°C 238-248°C (3-Bromo-5-nitrobenzoic acid)
Solubility Methanol-soluble Dependent on substituents

Key Advantage: Enhanced stability compared to halogen-substituted analogs, making it preferable for pharmaceutical synthesis.

2. Detailed Applications

Pharmaceutical Intermediates

Widely used in the synthesis of active pharmaceutical ingredients (APIs), particularly in:

  • Antibacterial agents
  • Non-steroidal anti-inflammatory drugs (NSAIDs)
  • Kinase inhibitors

Agrochemical Development

  • Key precursor for herbicides with selective action
  • Used in fungicide formulations

Material Science

  • Building block for liquid crystal materials
  • Polymer modification agent

3. Operational Guidelines

Handling & Storage

  • Store in airtight containers at 2-8°C
  • Use in well-ventilated areas with PPE (gloves, goggles)
  • Avoid contact with strong oxidizers

Reaction Optimization

  • Optimal coupling reactions: 0-5°C in anhydrous DMF
  • Catalyst recommendation: Pd(PPh3)4 for cross-coupling reactions

4. Case Studies

Case 1: Antibiotic Intermediate Synthesis

Client: European Pharma Company
Application: Synthesis of novel quinolone antibiotic
Result: 22% yield improvement compared to previous brominated analogs

Case 2: OLED Material Development

Client: Asian Electronics Manufacturer
Application: Electron transport layer material
Result: Achieved 15% higher luminescence efficiency

5. Client Success Stories

Shanghai Jixiang Bio-Technology

Application: NSAID precursor production
Outcome: Scaled production to 500kg/month with 99.5% purity

YuHan Chemical Co., Ltd.

Application: Custom synthesis for agrochemicals
Outcome: Developed patent-pending herbicide formula

6. Contact for Custom Solutions

For technical specifications, bulk pricing, or custom synthesis requirements:

Email: info@vivalr.com
Tel: (86) 15866781826

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