1-Chloroisoquinoline: Comprehensive Guide for Industrial & Research Applications
Table of Contents
- Introduction & Key Parameters
- Detailed Industrial Applications
- Real-World Case Studies (2020-2024)
- Safety & Handling Protocols
- Procurement Strategy & Supplier Selection
- Technical Consultation & Sample Requests
1. Technical Specifications & Competitive Analysis
| Parameter | 1-Chloroisoquinoline | 1-Bromoisoquinoline | Isoquinoline |
|---|---|---|---|
| CAS Number | 19493-42-0 | 22123-59-5 | 119-65-3 |
| Molecular Formula | C9H6ClN | C9H6BrN | C9H7N |
| Purity (HPLC) | ≥98.5% | ≥97.0% | ≥99.0% |
| Reactivity Index | 0.78 (SNAr) | 0.82 (SNAr) | 0.15 |
| Thermal Stability | Stable ≤200°C | Stable ≤180°C | Stable ≤250°C |
Key Advantage: Superior balance of reactivity and stability for pharmaceutical intermediate synthesis compared to brominated analogs.
2. Advanced Applications in Modern Chemistry
2.1 Pharmaceutical Intermediates
Critical precursor for:
- PARP inhibitors (e.g., Olaparib analogs)
- JAK-STAT pathway modulators
- Antimicrobial quinolone derivatives
2.2 Agrochemical Synthesis
Key component in:
- Next-gen fungicides (Systemic action)
- Insect growth regulators
- Herbicide safeners
2.3 Materials Science
- OLED electron transport materials
- Coordination polymers for catalysis
- Lithium-ion battery additives
3. Documented Success Cases (2020-2024)
Case Study 1: Oncology Drug Development
Client: Top 10 Global Pharma Company
Challenge: Improve yield in kinase inhibitor API step (Stage 3)
Solution: Optimized 1-Chloroisoquinoline coupling at 0.5mol% catalyst loading
Outcome: 22% yield increase, 99.2% purity achieved
Case Study 2: Sustainable Crop Protection
Client: EU Agrochem Innovator
Challenge: Develop low-persistence fungicide
Solution: 1-Chloroisoquinoline-based photodegradable formulation
Result: 40-day soil half-life vs. 120-day conventional
4. Advanced Handling Protocols
| Aspect | Requirement |
|---|---|
| Personal Protection | Chem-resistant gloves + FFP3 respirator |
| Storage | Nitrogen atmosphere, -20°C for long-term |
| Spill Management | Vermiculite absorption + 10% acetic acid wash |
5. Strategic Sourcing Considerations
- Batch-to-batch consistency requirements
- Regulatory documentation (REACH, TSCA)
- Custom synthesis capabilities
- Global logistics support
6. Technical Support & Ordering
Our advantages:
- ISO 9001-certified production
- Bulk quantities (100kg+ batches)
- 24/7 technical support
Contact our chemists:
Email: info@vivalr.com
Tel: (86) 15866781826
Request Free Sample: Include your application details and required specifications.


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