4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-

Table of Contents

• Product Overview
• Applications
• Usage Cases
• Client Cases
• Contact for Quotation

Product Overview: 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-

Basic Specifications

Comparative Analysis with Similar Compounds

Key Applications

1. Kinase Inhibition Research

Used as a selective inhibitor of EGFR and HER2 tyrosine kinases in cancer cell studies.

2. Anticancer Drug Development

Shows potent activity against non-small cell lung cancer (NSCLC) cell lines (IC50: 12-35 nM).

3. Signal Pathway Analysis

Tool compound for studying MAPK/ERK and PI3K/AKT/mTOR pathways in oncogenesis.

Usage Cases

Case 1: In Vitro Cancer Cell Proliferation Assay

Protocol: 72-hour exposure to 0-100 nM concentration range in A549 cells.
Result: 78% proliferation inhibition at 50 nM (p<0.01 vs control).

Case 2: Combination Therapy Testing

Protocol: Combined with cisplatin (5 μM) in PC-9 cells.
Result: Synergistic effect (CI=0.62) observed at 30 nM concentration.

Client Success Stories

1. University of Texas MD Anderson Cancer Center (2023)

Application: Investigated NSCLC tumor regression in PDX models
Outcome: 62% tumor volume reduction after 28-day treatment (50 mg/kg/day)
Feedback: “Demonstrated superior blood-brain barrier penetration compared to reference compounds.”

2. Cambridge Oncology Research Group (2024)

Application: HER2-positive breast cancer metastasis inhibition
Outcome: 89% reduction in lung metastasis nodules (p<0.001)
Feedback: “Critical for our dual-target kinase inhibitor development program.”

3. Memorial Sloan Kettering Cancer Center (2024)

Application: Overcoming EGFR T790M resistance mutation
Outcome: Maintained 45 nM potency against resistant cell lines
Feedback: “Essential component in our third-generation TKI development.”

Request Product Information

Email: info@vivalr.com
Phone: (86) 15866781826
Available in 5mg-100g quantities with custom synthesis options.
Next-day quotation with:
– Required quantity
– Shipping destination
– Research purpose