6,7-Dimethoxy-3,4-dihydroquinazoline-4-one

Product Name:6
7-Dimethoxy-3
4-dihydroquinazoline-4-one
CAS:13794-72-4
MFC10H10N2O3
MW:206.2
EINECS:635-063-9
MOL File:13794-72-4.mol

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6,7-Dimethoxy-3,4-dihydroquinazoline-4-one: Technical Guide

1. Product Overview & Specifications

Parameter Value
CAS Number 13794-72-4
Molecular Formula C10H10N2O3
Appearance White to off-white crystalline powder
Boiling Point 374.1 °C at 760 mmHg
Density 1.33 g/cm³
Refractive Index 1.601

2. Key Applications

This compound serves as a critical intermediate in pharmaceutical synthesis, particularly in the production of gefitinib, a tyrosine kinase inhibitor used in cancer therapy. Its structural properties enable:

  • Precision in API (Active Pharmaceutical Ingredient) manufacturing
  • High-purity synthesis of quinazoline derivatives
  • Development of targeted oncology medications

3. Usage Scenarios

Pharmaceutical Synthesis

Used under controlled conditions (GMP standards) for:

  • Multi-step organic reactions requiring methoxy-group stability
  • Catalytic hydrogenation processes
  • Purification via recrystallization (ethanol/water systems)

4. Client Case Studies

Case 1: Oncology Drug Development

Client: Beijing Lingbao Technology Co., Ltd.
Application: Synthesis of gefitinib impurities and intermediates
Outcome: Achieved 99.8% purity in final API batches, complying with ICH Q3A/B guidelines.

Case 2: Research Institute Collaboration

Client: Confidential (Major European Pharma)
Application: Development of novel kinase inhibitors
Outcome: Accelerated lead optimization phase by 40% through improved synthetic routes.

5. Contact for Technical Support

For analytical certificates, bulk pricing, or custom synthesis requirements:

Email: info@vivalr.com
Phone: (86) 15866781826

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