8-Fluoro-4-Hydroxyquinoline: Comprehensive Product Guide
Table of Contents
1. Product Overview & Specifications
8-Fluoro-4-Hydroxyquinoline (CAS No. 63010-71-9) is a fluorinated quinoline derivative with the molecular formula C9H6FNO and a molecular weight of 163.15 g/mol. This off-white to beige crystalline powder is primarily utilized in research and industrial applications.
Key Specifications:
| Parameter | Value | Comparison with 8-Hydroxyquinoline |
|---|---|---|
| Melting Point | 278–282°C | Higher thermal stability |
| Boiling Point | 316.6±22.0°C | Enhanced volatility under vacuum |
| LogP | 2.08 | Improved lipophilicity |
| PSA | 33.12 Ų | Reduced polarity |
2. Applications & Industrial Uses
This compound serves critical roles in:
- Pharmaceutical Intermediates: Synthesis of fluorinated APIs (e.g., antimicrobial agents)
- Agrochemical Development: Building block for herbicides with enhanced activity
- Coordination Chemistry: Ligand for metal-organic frameworks (MOFs)
- Material Science: Precursor for organic semiconductors
3. Safety & Handling Guidelines
| Hazard Code | Precautionary Measures |
|---|---|
| H302 | Avoid ingestion; use fume hood during handling |
| H318 | Wear ANSI-approved goggles and gloves |
Storage: Keep in airtight containers at 2–8°C, protected from light and moisture.
4. Case Studies & Client Examples
Case Study 1: Pharmaceutical Research (Shanghai PharmaTech)
Used as a key intermediate in developing novel fluoroquinolone antibiotics, achieving 92% yield optimization.
Case Study 2: Material Science (NanoMaterials Co., Ltd.)
Enabled synthesis of luminescent MOFs with 15% improved quantum efficiency for sensor applications.
5. Technical Support & Inquiry
For bulk orders, custom synthesis, or technical documentation:
Email: info@vivalr.com
Tel: (86) 15866781826
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