1. Product Overview & Specifications

2′-Deoxy-2′-fluoro-2′-C-methyluridine (CAS: 863329-66-2) is a fluorinated nucleoside analog with the molecular formula C₁₀H₁₃FN₂O₅. It serves as a critical intermediate in antiviral drug synthesis, particularly for hepatitis C virus (HCV) therapeutics.

Key Parameters

*Compared to related nucleotide analogs in antiviral research.

2. Key Applications

This compound is widely utilized in:

• Antiviral Drug Development: Core intermediate for HCV protease inhibitors like Sofosbuvir
• RNA Polymerase Studies: Mechanistic probes for viral replication inhibition
• Precision Medicine: Synthesis of targeted nucleotide analogs with reduced off-target effects

3. Usage Scenarios

Typical Workflow

1. Phosphoramidite activation under inert atmosphere
2. Controlled coupling with protected nucleoside precursors
3. Deprotection & purification via column chromatography

Optimization Tips

• Storage: -20°C under argon
• Reaction Solvents: Anhydrous acetonitrile/DMF
• Catalysts: 0.5M 5-ethylthio-1H-tetrazole in acetonitrile

4. Case Studies

Case 1: HCV Drug Manufacturing

Client: Top 10 Global Pharma Company
Challenge: Scale-up from mg to kg quantities while maintaining >99% chiral purity
Solution: Developed continuous flow synthesis protocol reducing impurities by 62%

Case 2: Antiviral Research

Client: University Research Consortium
Challenge: Custom fluorinated analogs for resistance studies
Solution: Delivered 15 structurally modified derivatives within 8 weeks

5. Contact for Custom Solutions

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