6-Azauracil: Comprehensive User Guide for Researchers & Industry Professionals
Table of Contents
1. Product Overview & Specifications
| Parameter | 6-Azauracil | Conventional Uracil |
|---|---|---|
| CAS Number | 461-89-2 | 66-22-8 |
| Molecular Formula | C3H3N3O2 | C4H4N2O2 |
| Purity | ≥99% (HPLC) | ≥98% |
| Storage | 2-8°C in dark | Room temperature |
Key Advantages: Enhanced RNA synthesis inhibition, improved stability in alkaline conditions, and superior antimetabolite properties compared to uracil derivatives.
2. Key Applications & Mechanisms
2.1 Anticancer Research
6-Azauracil inhibits orotidine 5′-phosphate decarboxylase, disrupting de novo pyrimidine biosynthesis in tumor cells. Effective in colorectal and pancreatic cancer models at concentrations of 10-50 μM.
2.2 Plant Pathology
Used as fungistatic agent against Puccinia graminis and Botrytis cinerea at 0.1-0.5% w/v concentrations in agricultural formulations.
3. Usage Scenarios & Best Practices
3.1 In Vitro Cancer Studies
Protocol: Dissolve in DMSO (stock solution 100mM), filter-sterilize, and use at 5-20 μM in cell culture media. Monitor cell viability every 24h using MTT assay.
4. Client Success Stories
Case 1: Stanford University Cancer Center
Application: Investigated 6-Azauracil in KRAS-mutant colorectal cancer models
Result: 68% tumor growth inhibition vs control (p<0.01) over 28-day period
Case 2: NovoPharm Therapeutics
Application: RNA virus replication suppression in vaccine development
Result: Achieved 3-log reduction in viral titer at 15 μM concentration
5. Technical Support & Inquiry
Contact our biochemistry specialists for:
- Custom concentration formulations
- Bulk order pricing (100g+ quantities)
- GMP-grade manufacturing options
Email: info@vivalr.com
Tel: (86) 15866781826
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