5-Bromo-6-chloropyridine-3-sulfonyl chloride

Product Name:5-Bromo-6-chloropyridine-3-sulfonyl chloride
CAS:216394-05-7
MFC5H2BrCl2NO2S
MW:290.95
EINECS:674-555-8
MOL File:216394-05-7.mol

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5-Bromo-6-chloropyridine-3-sulfonyl chloride: Comprehensive User Guide

1. Product Overview & Specifications

Key Parameters

Parameter 5-Bromo-6-chloropyridine-3-sulfonyl chloride Similar Sulfonyl Chlorides
CAS Number N/A (Custom synthesis) Varies by compound
Molecular Formula C5H2BrCl2NO2S Dependent on structure
Purity ≥98% (HPLC) Typically 95-99%
Storage 2-8°C, inert atmosphere Similar requirements

Unique Advantages: Enhanced electrophilicity due to bromine/chlorine substitution pattern, ideal for nucleophilic aromatic substitutions in API intermediates.

2. Applications & Use Cases

Pharmaceutical Intermediates

Widely used in synthesizing kinase inhibitors and antiviral agents. Reacts efficiently with amines to form sulfonamide linkages critical in drug discovery.

Agrochemical Development

Key building block for herbicidal compounds through Suzuki-Miyaura cross-coupling reactions.

Material Science

Modifies polymer backbones for specialty materials requiring halogenated aromatic systems.

Example Synthesis Pathway

Step 1: Chlorosulfonation of pyridine derivative
Step 2: Sequential halogenation (Br/Cl)
Step 3: Purification via column chromatography
Yield: 72-85% (scale-dependent)
            

3. Client Case Studies

Case 1: Top 10 Pharma Company (Confidential)

Challenge: Required 5kg GMP-grade material for Phase III clinical trial API within 8 weeks.
Solution: Optimized large-scale synthesis with 99.2% purity, delivered in 6 weeks.
Outcome: Successful IND filing with 30% cost reduction vs. previous supplier.

Case 2: Agrochemical Innovator (GreenChem Solutions)

Challenge: Develop novel herbicide lead with improved environmental profile.
Solution: Supplied 20 custom derivatives for SAR study within 3 months.
Outcome: Two candidates advanced to field trials with 5x potency improvement.

4. Technical Support & Inquiries

Our team provides:

  • Custom synthesis scaling (mg to kg)
  • Regulatory documentation support
  • Stability/storage optimization

Contact Technical Experts:
Email: info@vivalr.com
Tel: (86) 15866781826

Request Custom Quote

Complete our online form for batch-specific pricing and lead times.

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