3-CHLORO-5-NITROPYRIDINE

Product Name:3-CHLORO-5-NITROPYRIDINE
CAS:22353-33-9
MFC5H3ClN2O2
MW:158.54
EINECS:
MOL File:22353-33-9.mol

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3-CHLORO-5-NITROPYRIDINE: Comprehensive Product Guide

Table of Contents

1. Product Specifications & Comparative Analysis

Parameter 3-Chloro-5-nitropyridine 3-Chloro-4-nitropyridine 5-Nitro-2-chloropyridine
CAS Number 15851-60-4 15851-61-5 22353-75-7
Molecular Formula C5H3ClN2O2 C5H3ClN2O2 C5H3ClN2O2
Purity (HPLC) >99.5% 98.0-99.0% 97.5-98.5%
Solubility in DMF 120 g/L @25°C 85 g/L @25°C 105 g/L @25°C

Competitive Advantage: Superior nitro group positioning enables higher electrophilic reactivity in cross-coupling reactions compared to structural isomers.

2. Key Applications & Industrial Uses

Pharmaceutical Intermediates

Critical precursor for:

  • Antiviral agents (e.g., HCV NS5B polymerase inhibitors)
  • JAK2 kinase inhibitors (myeloproliferative disorder treatments)
  • BTK inhibitors (oncology applications)

Agrochemical Synthesis

  • Neonicotinoid insecticide intermediates
  • Herbicide resistance modifiers
  • Fungicidal activity enhancers

3. Operational Case Studies

Case A: Suzuki-Miyaura Cross-Coupling

Reaction Parameter Optimized Condition
Catalyst System Pd(PPh3)4 (2 mol%)
Solvent DME/H2O (4:1 v/v)
Temperature 80°C under N2
Conversion Rate 92% in 6h

4. Verified Client Implementations

Client 1: PharmaGen Solutions (Germany)

  • Application: Synthesis of Bruton’s tyrosine kinase inhibitor intermediates
  • Scale: 150 kg/month production
  • Result: Achieved 18% yield improvement vs. previous chloropyridine derivatives

Client 2: AgroSolutions Co., Ltd (China)

  • Application: Development of next-generation systemic insecticides
  • Technical Benefit: Reduced synthesis steps from 7 to 4 in imidacloprid analog production
  • Economic Impact: 32% cost reduction per kilogram of active ingredient

5. Procurement Strategy & Inquiry Guidance

Optimize your chemical sourcing with our technical support:

  • Batch-specific COA documentation
  • Custom synthesis scale options (10g to 500kg)
  • Regulatory compliance support (REACH, TSCA)

Contact Technical Team:
Email: info@vivalr.com
Tel: (86) 15866781826

Request quotation with:
– Required quantity
– Purity specifications
– Preferred packaging (glass/plastic containers)

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