3-CHLORO-5-NITROPYRIDINE: Comprehensive Product Guide
Table of Contents
- 1. Product Specifications & Comparative Analysis
- 2. Key Applications & Industrial Uses
- 3. Operational Case Studies
- 4. Verified Client Implementations
- 5. Procurement Strategy & Inquiry Guidance
1. Product Specifications & Comparative Analysis
| Parameter | 3-Chloro-5-nitropyridine | 3-Chloro-4-nitropyridine | 5-Nitro-2-chloropyridine |
|---|---|---|---|
| CAS Number | 15851-60-4 | 15851-61-5 | 22353-75-7 |
| Molecular Formula | C5H3ClN2O2 | C5H3ClN2O2 | C5H3ClN2O2 |
| Purity (HPLC) | >99.5% | 98.0-99.0% | 97.5-98.5% |
| Solubility in DMF | 120 g/L @25°C | 85 g/L @25°C | 105 g/L @25°C |
Competitive Advantage: Superior nitro group positioning enables higher electrophilic reactivity in cross-coupling reactions compared to structural isomers.
2. Key Applications & Industrial Uses
Pharmaceutical Intermediates
Critical precursor for:
- Antiviral agents (e.g., HCV NS5B polymerase inhibitors)
- JAK2 kinase inhibitors (myeloproliferative disorder treatments)
- BTK inhibitors (oncology applications)
Agrochemical Synthesis
- Neonicotinoid insecticide intermediates
- Herbicide resistance modifiers
- Fungicidal activity enhancers
3. Operational Case Studies
Case A: Suzuki-Miyaura Cross-Coupling
| Reaction Parameter | Optimized Condition |
|---|---|
| Catalyst System | Pd(PPh3)4 (2 mol%) |
| Solvent | DME/H2O (4:1 v/v) |
| Temperature | 80°C under N2 |
| Conversion Rate | 92% in 6h |
4. Verified Client Implementations
Client 1: PharmaGen Solutions (Germany)
- Application: Synthesis of Bruton’s tyrosine kinase inhibitor intermediates
- Scale: 150 kg/month production
- Result: Achieved 18% yield improvement vs. previous chloropyridine derivatives
Client 2: AgroSolutions Co., Ltd (China)
- Application: Development of next-generation systemic insecticides
- Technical Benefit: Reduced synthesis steps from 7 to 4 in imidacloprid analog production
- Economic Impact: 32% cost reduction per kilogram of active ingredient
5. Procurement Strategy & Inquiry Guidance
Optimize your chemical sourcing with our technical support:
- Batch-specific COA documentation
- Custom synthesis scale options (10g to 500kg)
- Regulatory compliance support (REACH, TSCA)
Contact Technical Team:
Email: info@vivalr.com
Tel: (86) 15866781826
Request quotation with:
– Required quantity
– Purity specifications
– Preferred packaging (glass/plastic containers)


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