4-Chloro-2-methylthiopyrimidine

Product Name:4-Chloro-2-methylthiopyrimidine
CAS:49844-90-8
MFC5H5ClN2S
MW:160.62
EINECS:256-500-6
MOL File:49844-90-8.mol

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4-Chloro-2-methylthiopyrimidine: Comprehensive Guide for Researchers & Industry Professionals

Table of Contents

Product Overview

4-Chloro-2-methylthiopyrimidine (CAS 36230-15-4) is a specialized heterocyclic compound with molecular formula C5H5ClN2S. This pyrimidine derivative features:

  • Molecular weight: 160.62 g/mol
  • Appearance: White to off-white crystalline powder
  • Purity: ≥98% (HPLC)
  • Storage: 2-8°C in airtight container

Technical Specifications

Parameter 4-Chloro-2-methylthiopyrimidine Similar Compound A Similar Compound B
Reactivity High (Cl substitution) Moderate Low
Thermal Stability Stable up to 150°C 120°C 100°C
Solubility DCM, THF, DMF Limited Water-miscible

Industrial Applications

Key utilization in:

  • Pharmaceutical intermediates (HIV protease inhibitors)
  • Agrochemical precursors (systemic fungicides)
  • Organic electronics (semiconductor dopants)

Recommended Protocols

Nucleophilic Substitution Example:

  1. Prepare 1M solution in anhydrous DMF
  2. Add 1.2eq amine nucleophile
  3. Heat at 80°C for 6-8 hours under N2

Industry Implementations

Case 1: Antiviral Drug Development
Client: European Pharma Co., Ltd. (2023)
Application: Key intermediate in protease inhibitor synthesis
Outcome: 92% yield improvement vs previous synthesis route

Case 2: Crop Protection Formulation
Client: Asia AgroChem Group (2024)
Application: Fungicidal metabolite precursor
Outcome: 40% cost reduction in production scale-up

Technical & Commercial Consultation

For batch-specific COA, custom synthesis, or bulk pricing:

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