3-Bromo-5-fluoropyridine

Product Name:3-Bromo-5-fluoropyridine
CAS:407-20-5
MFC5H3BrFN
MW:175.99
EINECS:
MOL File:407-20-5.mol

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3-Bromo-5-fluoropyridine: Comprehensive User Guide

1. Product Overview & Specifications

3-Bromo-5-fluoropyridine (CAS 407-20-5) is a halogenated pyridine derivative with broad utility in organic synthesis. Its molecular formula is C5H3BrFN, and it has a molecular weight of 175.99 g/mol.

Key Specifications:

Parameter Value
Appearance Colorless to pale yellow liquid
Density 1.7±0.1 g/cm³
Boiling Point 152.5±20.0 °C
Melting Point 24-28°C
Flash Point 46.0±21.8 °C

Safety Data:

  • Hazard Codes: H302 (Harmful if swallowed), H315 (Causes skin irritation), H318 (Causes serious eye damage), H335 (May cause respiratory irritation)
  • Precautionary Measures: Use PPE, avoid inhalation, and store in a cool, ventilated area.

2. Applications & Use Cases

3-Bromo-5-fluoropyridine serves as a critical intermediate in:

  • Pharmaceuticals: Synthesis of antiviral and anticancer agents.
  • Agrochemicals: Building block for herbicides and fungicides.
  • Material Science: Precursor for functionalized polymers and ligands.

Example Workflow:

In drug development, it is used to introduce fluorine and bromine substituents into pyridine rings, enhancing bioactivity and metabolic stability.

3. Industry Case Studies

Case Study 1: Shanghai Yuanye Bio-Technology Co., Ltd.

  • Application: Synthesis of fluorinated pyridine carboxylates for kinase inhibitors.
  • Outcome: Achieved 98% purity in final API intermediates, reducing downstream purification costs.

Case Study 2: HeWu Biochemical Co., Ltd.

  • Application: Development of novel agrochemical intermediates.
  • Outcome: Improved reaction yield by 22% compared to traditional bromination methods.

4. Contact for Inquiries

For pricing, technical data, or custom synthesis requests, contact our team:

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