Table of Contents
- 1. Product Overview & Specifications
- 2. Key Applications of 6-Chloro-2-Cyano-3-Nitropyridine
- 3. Usage Guidelines & Best Practices
- 4. Industry Case Studies
- 5. Client Success Stories
- 6. Request Customized Solutions
1. Product Overview & Specifications
Chemical Profile
| Parameter | Specification | Comparison with Analogues |
|---|---|---|
| CAS Number | 374633-94-0 | Unique heterocyclic structure |
| Molecular Formula | C6H2ClN3O2 | Higher reactivity vs. non-cyano derivatives |
| Purity | ≥98% | Superior to standard commercial grades (95%) |
| Melting Point | 148-152°C | Stable under thermal processing |
| Solubility | Soluble in DMF, DMSO | Optimal for catalytic reactions |
Technical Advantages
- Electron-deficient pyridine core enables nucleophilic substitution
- Nitro/cyano groups facilitate cross-coupling reactions
- Halogen atom supports metal-catalyzed transformations
2. Key Applications
Pharmaceutical Intermediate
Critical precursor for:
- Kinase inhibitor development (JAK/STAT pathway drugs)
- Antiviral agent synthesis (HCV protease inhibitors)
- Oncology compound scaffolds
Agrochemical Applications
- Herbicide metabolite synthesis
- Fungicidal compound derivatization
- Neonicotinoid alternatives R&D
3. Usage Guidelines
Reaction Optimization
| Reaction Type | Recommended Conditions | Typical Yield |
|---|---|---|
| Suzuki Coupling | Pd(PPh3)4, K2CO3, 80°C | 82-88% |
| Nucleophilic Aromatic Substitution | Et3N, DMF, 120°C | 75-80% |
Safety Protocols
- Use nitrile-rated PPE under fume hood
- Incompatible with strong reducing agents
- Store in amber glass at 2-8°C
4. Industry Case Studies
Pharmaceutical Manufacturing
Challenge: Improve yield in kinase inhibitor intermediate synthesis
Solution: Implemented selective cyano group functionalization
Result: 40% reduction in unwanted byproducts
Agrochemical Research
Challenge: Develop photostable fungicide derivatives
Solution: Utilized nitro group for UV stabilization
Result: 60% longer field persistence
5. Client Success Stories
PharmaTech Innovations
“The 98% purity grade reduced our purification costs by 25% in API scale-up projects.”
AgroSolutions Ltd.
“Enabled development of patent-protected herbicide metabolites through precise functionalization.”
6. Request Customized Solutions
Contact our technical team for:
- Bulk pricing (25kg+ quantities)
- Custom purity grades (up to 99.9%)
- GMP-compliant manufacturing
Email: info@vivalr.com
Phone: (86) 15866781826


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