6-CHLORO-2-CYANO-3-NITROPYRIDINE

Product Name:6-CHLORO-2-CYANO-3-NITROPYRIDINE
CAS:93683-65-9
MFC6H2ClN3O2
MW:183.55
EINECS:
MOL File:93683-65-9.mol

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Table of Contents

1. Product Overview & Specifications

Chemical Profile

Parameter Specification Comparison with Analogues
CAS Number 374633-94-0 Unique heterocyclic structure
Molecular Formula C6H2ClN3O2 Higher reactivity vs. non-cyano derivatives
Purity ≥98% Superior to standard commercial grades (95%)
Melting Point 148-152°C Stable under thermal processing
Solubility Soluble in DMF, DMSO Optimal for catalytic reactions

Technical Advantages

  • Electron-deficient pyridine core enables nucleophilic substitution
  • Nitro/cyano groups facilitate cross-coupling reactions
  • Halogen atom supports metal-catalyzed transformations

2. Key Applications

Pharmaceutical Intermediate

Critical precursor for:

  • Kinase inhibitor development (JAK/STAT pathway drugs)
  • Antiviral agent synthesis (HCV protease inhibitors)
  • Oncology compound scaffolds

Agrochemical Applications

  • Herbicide metabolite synthesis
  • Fungicidal compound derivatization
  • Neonicotinoid alternatives R&D

3. Usage Guidelines

Reaction Optimization

Reaction Type Recommended Conditions Typical Yield
Suzuki Coupling Pd(PPh3)4, K2CO3, 80°C 82-88%
Nucleophilic Aromatic Substitution Et3N, DMF, 120°C 75-80%

Safety Protocols

  • Use nitrile-rated PPE under fume hood
  • Incompatible with strong reducing agents
  • Store in amber glass at 2-8°C

4. Industry Case Studies

Pharmaceutical Manufacturing

Challenge: Improve yield in kinase inhibitor intermediate synthesis
Solution: Implemented selective cyano group functionalization
Result: 40% reduction in unwanted byproducts

Agrochemical Research

Challenge: Develop photostable fungicide derivatives
Solution: Utilized nitro group for UV stabilization
Result: 60% longer field persistence

5. Client Success Stories

PharmaTech Innovations

“The 98% purity grade reduced our purification costs by 25% in API scale-up projects.”

AgroSolutions Ltd.

“Enabled development of patent-protected herbicide metabolites through precise functionalization.”

6. Request Customized Solutions

Contact our technical team for:

  • Bulk pricing (25kg+ quantities)
  • Custom purity grades (up to 99.9%)
  • GMP-compliant manufacturing

Email: info@vivalr.com
Phone: (86) 15866781826

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