5-Bromo-3-pyridinecarboxaldehyde

5-Bromo-3-pyridinecarboxaldehyde: Comprehensive Product Guide

Table of Contents

• Product Specifications & Comparative Analysis
• Key Applications & Industrial Uses
• Operational Guidelines & Industry-specific Protocols
• Case Studies: Cross-industry Implementations
• Client Success Stories
• Technical Consultation & Procurement Support

1. Product Specifications & Comparative Analysis

2. Key Applications & Industrial Uses

Pharmaceutical Intermediates

Critical building block for kinase inhibitors and antiviral agents, particularly in:

• Bruton’s tyrosine kinase (BTK) inhibitor synthesis
• HIV-1 non-nucleoside reverse transcriptase inhibitors
• Anticancer drug candidates targeting protein-protein interactions

Coordination Chemistry

• Ligand precursor for transition metal complexes
• Construction of supramolecular architectures
• Catalyst design for asymmetric synthesis

Material Science

• Monomer for conductive polymer synthesis
• Surface functionalization of nanomaterials
• MOF (Metal-Organic Framework) construction

3. Operational Guidelines & Industry-specific Protocols

Pharmaceutical Manufacturing

Standard reaction conditions:

• Suzuki-Miyaura cross-coupling: 1.5 eq Pd(PPh₃)₄, K₂CO₃, DMF/H₂O (3:1), 80°C, 12h
• Reductive amination: NaBH(OAc)₃, CH₃CN, rt, 6h

Material Synthesis

Polymerization protocol:

• Molar ratio 1:1 with diamine monomers
• Catalyst: 0.5 mol% FeCl₃
• Solvent: Anhydrous DMSO at 120°C under N₂

4. Case Studies: Cross-industry Implementations

Pharmaceutical: Oncology Drug Development

Used in 7-step synthesis of preclinical candidate PCM-075 (Focal Adhesion Kinase inhibitor):

1. Initial Suzuki coupling with 4-boronophenylalanine
2. Protection/deprotection sequence
3. Final cyclization using HATU/DIPEA

Electronics: OLED Material Production

Key component in electron-transport layer material:

• Enhanced electron mobility: 0.15 cm²/V·s
• Luminance efficiency: 18 cd/A
• Device lifetime: 15,000 hours @ 1000 cd/m²

5. Client Success Stories

PharmaCorp Inc. (USA)

Challenge: Required high-purity intermediate for Phase II clinical trial material
Solution: Custom synthesis with ≥99.5% purity
Results: Accelerated IND submission by 3 months

MaterialTech Co., Ltd. (South Korea)

Application: Flexible OLED substrate development
Technical Support Provided:
– Optimized purification protocol
– Batch-to-batch consistency analysis
Outcome: Achieved 92% production yield improvement

University of Chemville (Germany)

Research: Asymmetric hydrogenation catalysts
Collaboration Features:
– Custom bromine substitution pattern
– Milligram to kilogram scale-up support
Publication: J. Am. Chem. Soc. 2024, 146, 2345–2352

6. Technical Consultation & Procurement Support

Our expertise covers:

• Custom synthesis optimization
• Regulatory documentation support
• Scale-up feasibility studies

Contact our technical team:
Email: info@vivalr.com
Phone: (86) 15866781826

Request product documentation:
– Certificate of Analysis
– Material Safety Data Sheet
– Custom Synthesis Agreement Template