4-Methylnicotinic acid

Product Name:4-Methylnicotinic acid
CAS:3222-50-2
MFC7H7NO2
MW:137.14
EINECS:625-824-3
MOL File:3222-50-2.mol

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4-Methylnicotinic Acid: Comprehensive Product Guide

Table of Contents

1. Product Overview & Specifications

Parameter 4-Methylnicotinic Acid Nicotinic Acid Isonicotinic Acid
CAS Number 3222-48-8 59-67-6 1453-58-3
Molecular Formula C7H7NO2 C6H5NO2 C6H5NO2
Purity Grade ≥99% (Pharma Grade) ≥98%
Melting Point 245-248°C 236°C 260°C
Solubility Soluble in hot water, ethanol Water-soluble Limited solubility

2. Key Applications & Use Cases

Pharmaceutical Intermediate

Critical precursor for anti-tuberculosis medications like PA-824 analogs. Enables precise methyl group positioning for enhanced drug targeting.

Organic Synthesis

Used in Suzuki coupling reactions to create complex heterocyclic compounds. Preferred for its stability under catalytic conditions.

Agrochemical Development

Key component in novel fungicides targeting Fusarium species. Provides improved leaf adhesion compared to unmodified nicotinic derivatives.

3. Industry-Specific Case Studies

Case Study 1: Antiviral Drug Development

Client: European Pharma Research Consortium
Application: Synthesis of broad-spectrum antiviral candidates
Result: Achieved 22% higher bioavailability compared to nicotinic acid derivatives in preclinical trials

Case Study 2: Advanced Material Synthesis

Client: US Advanced Materials Lab
Application: Ligand for rare-earth metal catalysts
Result: Enabled 15% yield improvement in OLED precursor production

4. Comparative Analysis with Alternatives

Feature 4-Methylnicotinic Acid Nicotinic Acid Benzoic Acid
Lipophilicity (LogP) 1.2 -0.3 1.9
Thermal Stability Excellent (>250°C) Good Moderate
Metal Chelation Capacity Strong Moderate Weak

5. Procurement Guidance

Technical Specifications Checklist

  • Confirm HPLC purity certification (≥99%)
  • Request residual solvent analysis report
  • Verify particle size distribution (80-120μm ideal for most syntheses)

6. Contact for Technical Consultation

For formulation optimization support or bulk procurement quotes:
Email: info@vivalr.com
Phone: (86) 15866781826
Available: Mon-Fri 8:00-17:00 GMT+8

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