5-Bromopyridine-3-boronic Acid: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
Key Parameters
| Parameter | Value |
|---|---|
| CAS Number | 1072941-68-1 |
| Molecular Formula | C5H4BBrNO2 |
| Molecular Weight | 220.81 g/mol |
| Purity | ≥97% (HPLC) |
| Appearance | White to off-white crystalline powder |
Comparative Analysis
| Feature | 5-Bromopyridine-3-boronic Acid | Standard Boronic Acids |
|---|---|---|
| Reactivity | High (pyridine ring enhances coupling efficiency) | Moderate |
| Solubility | Soluble in THF, DMF, DMSO | Limited in polar solvents |
2. Applications & Use Cases
Pharmaceutical Intermediates
Widely used in Suzuki-Miyaura cross-coupling reactions to synthesize kinase inhibitors and antiviral agents. Example reaction:
Step 1: 5-Bromopyridine-3-boronic Acid + Aryl Halide → Biaryl Compound (Catalyzed by Pd(PPh3)4)
Material Science
Essential for creating conjugated polymers in OLED displays. Enables precise control over electron-deficient pyridine moieties.
3. Client Success Stories
Case 1: Vertex Therapeutics
Application: Development of BTK inhibitor VX-548
Result: Achieved 92% yield in key coupling step
Feedback: “Superior reactivity vs. chloro-analogues reduced synthesis time by 40%”
Case 2: NanoPoly Materials
Application: Conductive polymer for flexible displays
Result: Enhanced electron mobility by 3.2× compared to thiophene-based systems
Feedback: “Critical for achieving commercial-grade conductivity”
4. Technical Support & Inquiry
Request product samples or technical documents:
- Email: info@vivalr.com
- Tel: (86) 15866781826
Our chemical engineers provide:
- Custom synthesis protocols
- Stability data under various conditions
- Regulatory compliance guidance
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