Product Name:5-Azacytosine
CAS:931-86-2
MFC3H4N4O
MW:112.09
EINECS:213-242-9
MOL File:931-86-2.mol
Parameter | 5-Azacytosine | 5-Aza-2'-Deoxycytidine | Zebularine |
---|---|---|---|
CAS Number | 320-67-2 | 2353-33-5 | 3690-10-6 |
Molecular Formula | C4H5N3O5 | C8H12N4O5 | C9H12N2O5 |
Mechanism | DNA/RNA methyltransferase inhibitor | DNA methylation inhibitor | Cytidine deaminase inhibitor |
Demethylation studies for cancer biomarker discovery and gene silencing reversal.
Used in hematologic malignancies (MDS, AML) at concentrations 0.5-10μM for 72hr exposure.
Induces somaclonal variation in crops at 25-100μM treatment for 2-4 weeks.
Application | Concentration | Duration |
---|---|---|
Cell Culture Treatment | 1-10 μM | 48-96 hours |
Plant Tissue Culture | 25-100 μM | 14-28 days |
Challenge: Reactivate tumor suppressor genes in lung adenocarcinoma
Solution: 5μM 5-Azacytosine + 0.5μM TSA for 72hr
Result: 40% reduction in promoter methylation (p<0.01)
Challenge: Enhance drought resistance in wheat
Solution: 50μM seed pretreatment for 24hr
Result: 22% improvement in water retention capacity
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