3-ACETYL-5-BROMOPYRIDINE

Comprehensive Guide to 3-Acetyl-5-Bromopyridine

Table of Contents

• Product Overview & Specifications
• Key Applications
• Industry Case Studies
• Usage Guidelines
• Contact for Custom Solutions

Product Overview & Specifications

3-Acetyl-5-Bromopyridine (CAS 100365-04-4) is a brominated pyridine derivative widely used as a building block in pharmaceuticals, agrochemicals, and material science.

Key Applications

Pharmaceutical Intermediates

Used in synthesis of kinase inhibitors, antiviral agents (e.g., Remdesivir analogs), and CNS drugs due to its bioisosteric properties.

Agrochemicals

Critical component in neonicotinoid insecticide development, providing enhanced pest resistance management.

Material Science

Building block for OLED electron-transport layers and metal-organic frameworks (MOFs) with luminescent properties.

Industry Case Studies

Case 1: Anticancer Drug Development

Client: Top 10 Global Pharma Company
Application: Synthesized third-generation BTK inhibitor
Result: Achieved 92% yield in Buchwald-Hartwig amination step
Feedback: “Superior regioselectivity compared to alternative bromopyridines”

Case 2: Next-Gen Insecticides

Client: European Agrochemical Leader
Application: Developed soil-stable systemic insecticide
Result: 40% longer residual activity vs. previous formulation
Feedback: “Consistent lot-to-lot purity ensured scalable production”

Usage Guidelines

Handling Precautions

• Store at 2-8°C under inert atmosphere
• Use nitrile gloves and chemical goggles
• Solubility: 50 mg/mL in DMF or DMSO

Reaction Optimization

• Cross-coupling: Use Pd(dppf)Cl₂ catalyst at 80-100°C
• Grignard reactions: Maintain strict anhydrous conditions

Request Customized Solutions

Available in quantities from 100mg to 100kg. Custom purity (up to 99.9%), isotopic labeling, and bulk API integration services.

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