2,6-Difluoropyridine

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Table of Contents

1. Product Overview & Specifications

1.1 Chemical Properties

2,6-Difluoropyridine (CAS 110553-19-4) is a fluorinated heterocyclic compound with molecular formula C5H3F2N. Key parameters:

Parameter Value
Purity ≥99% (HPLC)
Melting Point -14°C to -12°C
Boiling Point 132-134°C
Density 1.293 g/cm³
Refractive Index 1.443

1.2 Grade Comparison

Grade Pharmaceutical Industrial Research
Purity ≥99.9% ≥98% ≥95%
Impurity Profile ICH compliant Standard Basic
Packaging Nitrogen-sealed Vacuum-packed Ambient

2. Key Applications

2.1 Pharmaceutical Intermediates

Critical component in synthesizing:

  • Kinase inhibitors (e.g., EGFR inhibitors)
  • Antiviral agents
  • PET radiopharmaceuticals

2.2 Agrochemical Formulations

Used in next-generation:

  • Herbicides (Fluoropyridine-class)
  • Insect growth regulators

3. Usage Guidelines

3.1 Handling Protocols

  • Storage: -20°C under inert gas
  • Shelf Life: 24 months unopened

3.2 Reaction Optimization

Reaction Type Catalyst Yield Range
Suzuki Coupling Pd(PPh3)4 78-85%
Buchwald-Hartwig XPhos Pd G3 82-90%

4. Industry Case Studies

4.1 Drug Development

Challenge: Improve solubility of oncology compound
Solution: 2,6-Difluoropyridine backbone modification
Result: 40% bioavailability increase

5. Client Success Stories

5.1 Top-tier Pharma Company (Confidential)

  • Application: EGFR inhibitor development
  • Volume: 150kg/year
  • Outcome: Accelerated IND filing by 6 months

5.2 Agrochemical Leader

  • Project: Herbicide resistance management
  • Result: 92% weed control efficacy

6. Request Customized Solutions

Contact our technical team for:

  • Bulk pricing (50kg+ orders)
  • Custom fluorination services
  • Regulatory support packages

Email: info@vivalr.com
Phone: (86) 15866781826

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