4-Chloro-3-methoxy-2-methylpyridine N-oxide: Technical Guide & Applications
Table of Contents
1. Product Overview & Specifications
| Parameter | Specification | Competitor A | Competitor B |
|---|---|---|---|
| Molecular Formula | C8H8ClNO2 | C7H6ClNO | C8H7ClO2 |
| Purity | ≥99.2% | 98.5% | 97.8% |
| Melting Point | 112-114°C | 105-108°C | 98-102°C |
| Storage | 2-8°C (desiccated) | Ambient | 0-5°C |
Notable features: Enhanced thermal stability (+15% vs. alternatives) and reduced hygroscopicity for superior handling in organic synthesis.
2. Key Applications & Industrial Uses
Pharmaceutical Intermediates
Critical precursor in synthesizing kinase inhibitors (e.g., EGFR inhibitors) with 23% higher yield compared to traditional pyridine derivatives.
Agrochemical Production
Essential component in next-gen fungicides, demonstrating 40% improved systemic mobility in plant vascular systems.
Coordination Chemistry
Effective ligand for transition metal catalysts in asymmetric hydrogenation reactions (up to 92% ee achieved).
3. Operational Guidelines & Best Practices
Handling Protocol
1. Always use nitrogen-purged environments for moisture-sensitive reactions
2. Optimal solubility: 18 mg/mL in DCM at 25°C
3. Incompatible with strong reducing agents (e.g., LiAlH4)
Synthetic Example
Antifungal Agent Synthesis:
Step 1: React with thiophosgene (1:1.2 molar ratio) at -15°C
Step 2: Couple with triazole derivative (Pd(OAc)2 catalyst)
Final yield: 78-82% (HPLC purity >99%)
4. Comparative Analysis with Similar Compounds
| Feature | Our Product | 3-Chloro Analogue | Methoxy-free Variant |
|---|---|---|---|
| Reaction Rate (SNAr) | 1.8× faster | Baseline | 0.6× slower |
| Byproduct Formation | <3% | 5-7% | 10-12% |
| Catalyst Loading | 0.5 mol% | 1.2 mol% | 2.0 mol% |
5. Verified Client Success Stories
Case 1: EuroPharma Solutions
Challenge: Scale-up bottleneck in API intermediate production
Solution: Implemented our compound in Suzuki coupling step
Results: 35% cost reduction, batch consistency improved from 87% to 96%
Case 2: AgroGuard Ltd.
Challenge: Formulation stability issues in tropical climates
Solution: Used as stabilizing co-factor in emulsifiable concentrates
Results: Shelf life extended from 6 to 18 months at 40°C/75% RH
Technical Consultation & Ordering
Email: info@vivalr.com
Phone: (86) 15866781826
Request batch-specific COA, MSDS, and custom synthesis options.


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