2,4-Dichloro-5-methylpyrimidine

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2,4-Dichloro-5-methylpyrimidine Technical Guide

Table of Contents

Product Specifications & Comparative Analysis

Parameter 2,4-Dichloro-5-methylpyrimidine Analogous Compounds
CAS Number 3934-20-1 (Structural variant) 954220-98-5 (Fluorinated analog)
Molecular Formula C5H4Cl2N2 C5H3Cl2FN2
Molecular Weight 163.0 g/mol 181.0 g/mol
Physical State White crystalline solid Off-white powder
Storage 2-8°C under inert atmosphere Ambient (desiccated)

Industrial Applications

This heterocyclic compound serves as critical intermediate in:

  • Pharmaceutical synthesis (kinase inhibitor precursors)
  • Agrochemical production (herbicide metabolites)
  • Organic electronic material development
  • Cross-coupling reactions in catalytic systems

Operational Guidelines

Optimal handling protocols:

  1. Use dry glassware under nitrogen purge for reactions
  2. Maintain reaction temperatures below -10°C during lithiation
  3. Employ palladium catalysts for Suzuki-Miyaura couplings
  4. Quench residual activity with ammonium chloride solutions

Implementation Case Studies

Case 1: Antiviral Drug Intermediate Synthesis

A Shanghai-based pharmaceutical manufacturer achieved 92% yield in nucleoside analog production through optimized Buchwald-Hartwig amination using this compound as core substrate.

Case 2: Crop Protection Formulation

Jiangsu Agrochemicals developed broad-spectrum fungicides demonstrating 98% pathogen inhibition through strategic derivatization of the methylpyrimidine backbone.

Procurement Consultation

For technical specifications sheets or bulk pricing:

Email: info@vivalr.com
Tel: (86) 15866781826

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