4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Comprehensive Guide
Table of Contents
1. Product Specifications
| Parameter | 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine | Derivative Comparison |
|---|---|---|
| CAS Number | 5399-92-8 | 852314-01-3 (Chlorophenyl variant) |
| Molecular Formula | C5H3ClN4 | C13H11ClN4 (Dimethylphenyl variant) |
| Molecular Weight | 154.56 g/mol | 258.71 g/mol |
| Melting Point | 102-104°C | 110-112°C |
| Storage | 2-8°C in dry environment | Room temperature (derivative-specific) |
2. Industrial Applications
Pharmaceutical Development
Serves as key intermediate in kinase inhibitor production for oncology treatments. Particularly valuable in Bruton’s tyrosine kinase (BTK) inhibitor synthesis.
Agrochemical Research
Used in development of next-generation fungicides with enhanced environmental stability. Demonstrated 40% higher efficacy than traditional triazole compounds in field trials.
Material Science
Component in organic semiconductor materials for flexible electronics. Enables electron mobility up to 2.3 cm²/V·s in thin-film transistors.
3. Synthesis Protocols
Primary Synthesis Route
81% yield achieved through condensation of 4,6-dichloro-5-pyrimidinecarbaldehyde with hydrazine hydrate under nitrogen atmosphere (reflux at 110°C for 8 hours).
Alternative Method
Microwave-assisted synthesis reduces reaction time to 90 minutes with comparable 75% yield. Requires specialized equipment but improves production throughput by 300%.
4. Industry Implementations
Case Study 1: Oncology Drug Development
Client: Top 10 Global Pharma Company
Application: BTK inhibitor intermediate production
Results: Achieved 99.2% purity in GMP-grade batches, supporting Phase III clinical trials
Case Study 2: Agricultural Formulation
Client: EU-based Agrochemical Producer
Application: Systemic fungicide for cereal crops
Results: 22% yield improvement in final formulation compared to previous active ingredient
Case Study 3: Electronic Materials
Client: Asian OLED Manufacturer
Application: Electron transport layer material
Results: Enabled 15% energy efficiency improvement in flexible displays
5. Procurement Information
| Package Size | Purity | Lead Time | MOQ |
|---|---|---|---|
| 5g | 98% | 2 weeks | $450 |
| 25g | 99% | 3 weeks | $1,850 |
| 100g | 99.5% | 4 weeks | $6,200 |
6. Request Custom Quote
For bulk orders (>1kg) or formulation development support:
Email: info@vivalr.com
Phone: (86) 15866781826
Technical support available for:
– Custom synthesis scaling
– Analytical method development
– Regulatory documentation preparation
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