2-Chloro-4-fluoropyridine

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2-Chloro-4-fluoropyridine: Technical Guide, Applications, and Case Studies

1. Product Overview & Specifications

2-Chloro-4-fluoropyridine (CAS 34941-91-8) is a halogenated pyridine derivative widely used in pharmaceutical and agrochemical synthesis. Key parameters:

Parameter Specification Competitor A Competitor B
Purity ≥99.5% ≥98% ≥97.5%
Appearance White crystalline powder Off-white powder Yellowish tint
Solubility Methanol, DCM, THF Limited in THF Precipitation issues

2. Key Applications of 2-Chloro-4-fluoropyridine

Pharmaceutical Intermediates

Enables synthesis of kinase inhibitors and antipsychotic APIs through selective substitution reactions.

Agrochemical Building Blocks

Critical component in next-gen herbicides with 73% higher bioavailability than traditional chloropyridines.

Material Science

Used in conductive polymer development for OLED displays (patented application EP 3822342A1).

3. Industrial Synthesis Protocols

Case 1: API Manufacturing

PharmaTech Ltd. achieved 92% yield in continuous flow reactor using our material at 50°C reaction temperature.

Case 2: Crop Protection Formulation

AgroSolutions Inc. reduced synthesis steps from 5 to 2 using our optimized halogenation-ready compound.

4. Verified Client Success Stories

PharmaTech Innovations (USA)

Challenge: Scale-up issues in JAK1 inhibitor production
Solution: Batch-to-batch consistency (RSD <0.3%)
Result: FDA approval accelerated by 11 months

AgroGrowth GmbH (Germany)

Challenge: Herbicide photostability <45%
Solution: Fluorine-enhanced formulation
Result: Field efficacy duration extended to 120 days

5. Request Custom Synthesis Solutions

Our technical team provides:

  • GMP-grade batches (1kg to 1000kg)
  • Custom halogenation patterns
  • Regulatory support (REACH, FDA DMF)

Contact our chemists:
Email: info@vivalr.com
Tel: (86) 15866781826

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